Development of artemether-loaded nanostructured lipid carrier (NLC) formulation for topical application
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TL;DR: Ex vivo study proves that ART permeates excised human epidermis, where the current formulation served as a reservoir to gradually control drug release over an extended period of time and may be a positive signal to hope for a topical delivery system of ART.
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About: This article is published in International Journal of Pharmaceutics. The article was published on 30 Dec 2014. and is currently open access.
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Citations
Solid lipid nanoparticles and nanostructured lipid carriers as novel drug delivery systems: applications, advantages and disadvantages.
TL;DR: The aim of this article is to review the advantages and limitations of these delivery systems based on the route of administration and to emphasis the effectiveness of such formulations.
Nanostructured lipid carriers: Promising drug delivery systems for future clinics.
Ana Beloqui,María Ángeles Solinís,Alicia Rodríguez-Gascón,António J. Almeida,Véronique Préat +4 more
TL;DR: The understanding of the nanostructured lipid carriers (NLC)-based formulations has improved with continuing research recently, and the result has seen an increase in the use of these in the clinical setting.
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SLN and NLC for topical, dermal, and transdermal drug delivery.
Eliana B. Souto,Eliana B. Souto,Iara Baldim,Iara Baldim,Wanderley Pereira de Oliveira,Rekha Rao,Nitesh Yadav,Francisco M. Gama,Sheefali Mahant +8 more
TL;DR: This review focuses on Solid lipid nanoparticles (SLN) and Nanostructured lipid carriers (NLC) for skin administration, which are composed of lipids that resemble those of the skin and sebum, which contribute to their enhanced biocompatibility, with limited toxicological risk.
251
In vitro skin models as a tool in optimization of drug formulation
Gøril Eide Flaten,Zora Palac,André Engesland,Jelena Filipović-Grčić,Željka Vanić,Nataša Škalko-Basnet +5 more
TL;DR: This review attempts to provide an unbiased overview of the most commonly used in vitro models, with emphasis on their limitations and advantages.
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Nanostructured lipid carriers: A potential use for skin drug delivery systems.
TL;DR: In this paper, the authors present properties, methods of preparation and tests to assess the quality and toxicity of nanostructured lipid carriers (NLC) for dermal and transdermal drug application.
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References
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Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) -- structural investigations on two different carrier systems.
TL;DR: Two different types of colloidal lipid particles are presented and compared as innovative carrier systems and reasons for observed differences in loading capacity are discussed and possibilities for dermal application are described.
Further characterization of theobroma oil–beeswax admixtures as lipid matrices for improved drug delivery systems
TL;DR: Modifications of mixtures of beeswax and theobroma oil could be applied in the formulation of solid lipid nanoparticles and nanostructured lipid carriers as these lipid matrices possessed crystal characteristics that favour such drug delivery systems.
Artemether–lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with Plasmodium falciparum malaria after returning from Tanzania
Anna Färnert,Johan Ursing,Johan Ursing,Thomas Tolfvenstam,Thomas Tolfvenstam,Josea Rono,Lillemor Karlsson,Elda Sparrelid,Niklas Lindegardh,Niklas Lindegardh +9 more
TL;DR: Potential sub-optimal effect of artemether-lumefantrine highlights the need to follow non-immune individuals the weeks after treatment, and a treatment failure despite adequate drug concentrations in a traveller returning from sub-Saharan Africa is described.