Development of a Peptide Reactivity Assay for Screening Contact Allergens

TL;DR: It is shown that it is better to follow a preferential sequence than testing chemicals simultaneously with these three methods, which focuses on three in vitro methods that covered the first three steps of the AOP (DPRA, SENS-IS or h-CLAT).

TL;DR: The overall Japanese recommendation is that the ICH S6 guideline should be updated to address new types of biopharmaceuticals such as bioconjugates, use of homologous proteins and transgenic animals, reproductive/developmental toxicity studies in non-human primates, in vitro cardiac ion channel assay and alternative approaches for carcinogenicity assessment.

TL;DR: The modelling exercise showed that skin sensitisation hazard was better predicted by classification trees based on in silico predictions, and a defined approach was built based on readouts from various information sources that uses a fixed procedure for generating a prediction.

TL;DR: This prospective experiment showed the potential of real-time SPR to generate specific report points to refine the skin sensitization allergen assessment.

TL;DR: The Dichotomous Data Problem as discussed by the authors, the Two-Sample Dispersion Problem, and Other Two--Sample Problems are the most commonly used problems in survival analysis. But they do not consider the two-way layout.

TL;DR: High levels of cellular GSH levels in cultured cells in response to hyperoxia or electrophilic agents such as diethylmaleate is coupled with an increase in activity of the Xc- transport system for the amino acids cystine and glutamate.

TL;DR: High-performance liquid chromatography (HPLC) provides a rapid, sensitive, and reproducible means of separating and quantifying simultaneously a variety of sulfur-containing amino acids and related derivatives.