Development of a Peptide Reactivity Assay for Screening Contact Allergens
G. Frank Gerberick,Jeffrey D. Vassallo,Ruth E. Bailey,Joel G. Chaney,Morrall Stephen William,Jean-Pierre Lepoittevin +5 more
515
TL;DR: The data presented show that measuring peptide reactivity has utility for screening chemicals for their skin sensitization potency and thus potential for reducing the authors' reliance on animal test methods.
read more
About: This article is published in Toxicological Sciences. The article was published on 01 Oct 2004. and is currently open access. The article focuses on the topics: Sensitization & Local lymph node assay.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
The borderline range of toxicological methods: Quantification and implications for evaluating precision.
Maria Leontaridou,Daniel Urbisch,Susanne N. Kolle,Katharina Ott,Denis S. Mulliner,Silke Gabbert,Robert Landsiedel +6 more
TL;DR: The standard binary classification of substances is proposed to be expanded by adding a "borderline" or "inconclusive" alert for cases where test results fall within the borderline range.
Research Situation of in Vitro Alternative Methods to Evaluate Skin Sensitization
HONG Li-ling,ZHOU Qing-yun +1 more
TL;DR: This study reviews recent in vitro alternative methods to evaluate skin sensitization, replacing traditional guinea pig tests due to their long cycle, subjective results, and animal welfare concerns, highlighting the need for more efficient and humane testing methods.
Update to RIFM fragrance ingredient safety assessment, 2-ethylbutyric acid, CAS Registry Number 88-09-5.
A.M. Api,A. Bartlett,Donald V. Belsito,Danielle Botelho,Magnus Bruze,A. Bryant-Freidrich,G. A. Burton,M. A. Cancellieri,Hung-Che Chon,M.L. Dagli,Wolfgang Dekant,C. Deodhar,K. Farrell,A. Fryer,L. Jones,K. Joshi,A. Lapczynski,M. Lavelle,I-Pang Lee,H. Moustakas,J. Muldoon,T. Penning,G. Ritacco,N. Sadekar,I. Schember,Terry W Schultz,F. Siddiqi,I. Glenn Sipes,Gerry Sullivan,Y. Thakkar,Yoshinori Tokura +30 more
TL;DR: RIFM conducted a safety assessment of 2-ethylbutyric acid (CAS 88-09-5), evaluating 7 human health endpoints and environmental concerns, and cleared all endpoints using target data, read-across, and/or TTC.
Building scientific confidence in the development and evaluation of read-across.
TL;DR: The deliberations of the Cefic LRI read-across team in characterizing scientific confidence in the development and evaluation of read-ACross are summarized.
New approach methods for assessing indoor air toxicity
Marika Mannerström,Markéta Dvořáková,L. Svobodova,Marian Rucki,F Kotal,Adam Vavrouš,Věra Vrbíková,Kristina Kejlová,Dagmar Jírová,Tuula Heinonen +9 more
TL;DR: In this article , the authors used new approach methods to assess the potential toxicity of indoor air condensates using different in vitro test methods including cyto-and immunotoxicity, skin sensitization and endocrine disruption.
References
Hard and soft acids and bases
TL;DR: In this paper, the rate data for the generalized nucleophilic displacement reaction were reviewed, and the authors presented a method to estimate the rate of the generalized displacement reaction in terms of the number of nucleophiles.
9.5K
Nonparametric Statistical Methods
TL;DR: The Dichotomous Data Problem as discussed by the authors, the Two-Sample Dispersion Problem, and Other Two--Sample Problems are the most commonly used problems in survival analysis. But they do not consider the two-way layout.
2.4K
Regulation of cellular glutathione.
Susan M. Deneke,Barry L. Fanburg +1 more
TL;DR: High levels of cellular GSH levels in cultured cells in response to hyperoxia or electrophilic agents such as diethylmaleate is coupled with an increase in activity of the Xc- transport system for the amino acids cystine and glutamate.
921
High-performance liquid chromatography of thiols and disulfides: dinitrophenol derivatives.
Marc W. Fariss,Donald J. Reed +1 more
TL;DR: High-performance liquid chromatography (HPLC) provides a rapid, sensitive, and reproducible means of separating and quantifying simultaneously a variety of sulfur-containing amino acids and related derivatives.
524