Development of a Peptide Reactivity Assay for Screening Contact Allergens
G. Frank Gerberick,Jeffrey D. Vassallo,Ruth E. Bailey,Joel G. Chaney,Morrall Stephen William,Jean-Pierre Lepoittevin +5 more
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TL;DR: The data presented show that measuring peptide reactivity has utility for screening chemicals for their skin sensitization potency and thus potential for reducing the authors' reliance on animal test methods.
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About: This article is published in Toxicological Sciences. The article was published on 01 Oct 2004. and is currently open access. The article focuses on the topics: Sensitization & Local lymph node assay.
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Citations
Skin sensitizing effects of sulfur mustard and other alkylating agents in accordance to OECD guidelines.
Dirk Steinritz,Simon Lang,Tanja Popp,Markus Siegert,Simone Rothmiller,Andreas Kranawetvogl,Annette M. Schmidt,Harald John,Thomas Gudermann,Horst Thiermann,Kai Kehe +10 more
TL;DR: The skin sensitizing potential of SM and three related alkylating agents (AAs) was assessed following the OECD test guidelines and a tentative AOP for SM-induced skin sensitization is suggested.
6
CHAPTER 9:Integrated Approaches to Safety Testing: General Principles and Skin Sensitization as Test Case
Andreas Natsch
- 31 Oct 2013
TL;DR: The principle limitations of in vitro testing which may be overcome by an ITS are described and the theoretical frame of how data from different sources can be integrated is discussed to systematically present possibilities for data integration for the skin sensitization endpoint.
6
Effect of Fluorination on Skin Sensitization Potential and Fragrant Properties of Cinnamyl Compounds
Julie Charpentier,Roger Emter,Heinz Koch,Dominique Lelievre,Xavier Pannecoucke,Samuel Couve-Bonnaire,Andreas Natsch,Agnes Bombrun +7 more
TL;DR: In vitro evaluation of the skin sensitizing properties with three different assays indicates that α‐fluorination of Michael acceptor systems 1 and 3 slightly improves theSkin sensitization profile.
6
•Dissertation
Identification et caractérisation des peptides hapténisés avec la benzylpénicilline responsables de l’activation des cellules T naïves et de l’immunisation des patients allergiques à la pénicilline
Marie Eliane Azoury
- 23 Mar 2016
TL;DR: In this paper, the authors present a method to identify peptidiques issus de the HSA haptenisees avec the BP, impliquees dans l'activation des cellules T naives ainsi que l’immunisation des patients allergiques and par consequent les manifestations cliniques.
6
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