Development of a Peptide Reactivity Assay for Screening Contact Allergens
G. Frank Gerberick,Jeffrey D. Vassallo,Ruth E. Bailey,Joel G. Chaney,Morrall Stephen William,Jean-Pierre Lepoittevin +5 more
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TL;DR: The data presented show that measuring peptide reactivity has utility for screening chemicals for their skin sensitization potency and thus potential for reducing the authors' reliance on animal test methods.
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About: This article is published in Toxicological Sciences. The article was published on 01 Oct 2004. and is currently open access. The article focuses on the topics: Sensitization & Local lymph node assay.
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Citations
Matrix Effect of Human Reconstructed Epidermis on the Chemoselectivity of a Skin Sensitizing α-Methylene-γ-Butyrolactone: Consequences for the Development of in Chemico Alternative Methods.
Camille Debeuckelaere,Valérie Berl,Karim Elbayed,François-Marie Moussallieh,Izzie Jacques Namer,Jean-Pierre Lepoittevin +5 more
TL;DR: The role of histidine in the induction of skin sensitization has been so far neglected and should probably be taken into account for the refinement of in chemico approaches for the detection and potency classification of skin sensitizers.
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Development of a multiparametric in vitro model of skin sensitization
Muriel Guyard-Nicodème,Muriel Guyard-Nicodème,Eloïse Gerault,Marion Platteel,Olivier Peschard,Wilfried Veron,Philippe Mondon,Svinareff Pascal,Marc G. J. Feuilloley +8 more
TL;DR: A model of four tests appears as a promising technique to evaluate in vitro the skin sensitization potential of unknown molecules.
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Prediction of Skin Sensitizers using Alternative Methods to Animal Experimentation
Henrik Johansson,Malin Lindstedt +1 more
TL;DR: It is proposed that integrated testing strategies should comprise complementary assays, providing measurements of a wide range of mechanistic events, to perform well-educated risk assessments based on weight of evidence.
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Peptide reactivity assay using spectrophotometric method for high-throughput screening of skin sensitization potential of chemical haptens.
TL;DR: Results demonstrate that spectrophotometric methods can be easy, fast, and high-throughput screening tools for the prediction of the skin sensitization potential of chemical haptens.
11
References
Hard and soft acids and bases
TL;DR: In this paper, the rate data for the generalized nucleophilic displacement reaction were reviewed, and the authors presented a method to estimate the rate of the generalized displacement reaction in terms of the number of nucleophiles.
9.5K
Nonparametric Statistical Methods
TL;DR: The Dichotomous Data Problem as discussed by the authors, the Two-Sample Dispersion Problem, and Other Two--Sample Problems are the most commonly used problems in survival analysis. But they do not consider the two-way layout.
2.4K
Regulation of cellular glutathione.
Susan M. Deneke,Barry L. Fanburg +1 more
TL;DR: High levels of cellular GSH levels in cultured cells in response to hyperoxia or electrophilic agents such as diethylmaleate is coupled with an increase in activity of the Xc- transport system for the amino acids cystine and glutamate.
921
High-performance liquid chromatography of thiols and disulfides: dinitrophenol derivatives.
Marc W. Fariss,Donald J. Reed +1 more
TL;DR: High-performance liquid chromatography (HPLC) provides a rapid, sensitive, and reproducible means of separating and quantifying simultaneously a variety of sulfur-containing amino acids and related derivatives.
524