Development of a Peptide Reactivity Assay for Screening Contact Allergens

TL;DR: A limited trend was demonstrated, consistent with the hypothesis, but indicating that either skin irritation is a poor measure of danger signals, or that such signals are perhaps no more than a necessary requirement for the acquisition of skin sensitization rather than a key determinant of the relative potency of a skin sensitizing chemical.

TL;DR: Thimerosal induced U937 activation via oxidative stress from mitochondrial stores and mitochondrial membrane depolarization with a primordial effect of thiol groups, suggesting that Ca2- influx is a secondary event following ROS induction as Ca2+ influx was suppressed after pretreatment with NAC but not with thiol-independent antioxidants.

TL;DR: An overview of studies regarding PPD penetration through skin (analogues and studies on the amino acids that are targeted by PPD) and the auto‐oxidation and N‐acetylation steps involved in PPD metabolism are described.

TL;DR: Nanotechnology-based scaffolds are promising platforms for wound healing, especially due to their similarity to the extracellular matrix and their capability to promote cell adhesion and proliferation, and to restore skin integrity, when grafted into the wound site.

TL;DR: The Dichotomous Data Problem as discussed by the authors, the Two-Sample Dispersion Problem, and Other Two--Sample Problems are the most commonly used problems in survival analysis. But they do not consider the two-way layout.

TL;DR: High levels of cellular GSH levels in cultured cells in response to hyperoxia or electrophilic agents such as diethylmaleate is coupled with an increase in activity of the Xc- transport system for the amino acids cystine and glutamate.

TL;DR: High-performance liquid chromatography (HPLC) provides a rapid, sensitive, and reproducible means of separating and quantifying simultaneously a variety of sulfur-containing amino acids and related derivatives.