Development of a marrow transplant regimen for acute leukemia using targeted hematopoietic irradiation delivered by 131I-labeled anti-CD45 antibody, combined with cyclophosphamide and total body irradiation
Dana C. Matthews,FR Appelbaum,Janet F. Eary,D R Fisher,D R Fisher,D R Fisher,Lawrence D. Durack,Sharon A. Bush,T E Hui,P.J. Martin,David A. Mitchell,Oliver W. Press +11 more
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TL;DR: It is demonstrated that with the use of 131I-BC8 substantially greater doses of radiation can be delivered to hematopoietic tissues as compared with liver, lung, or kidney, which may improve the efficacy of marrow transplantation.
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About: This article is published in Blood. The article was published on 15 Feb 1995. and is currently open access. The article focuses on the topics: Total body irradiation & Acute lymphocytic leukemia.
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Citations
•Journal Article
Comparative metabolism and retention of iodine-125, yttrium-90, and indium-111 radioimmunoconjugates by cancer cells
Oliver W. Press,Darning Shan,Janet Howell-Clark,Janet F. Eary,Frederick R. Appelbaum,Dana C. Matthews,David J. King,Adrian M. R. Haines,Hamann Philip Ross,Lois M Hinman,Daniel Shochat,Irwin D. Bernstein +11 more
TL;DR: It is suggested that antibodies are routed to lysosomes after endocytosis, where they are proteolytically degraded and rapidly excreted from cells after lysOSomal catabolism of antibodies radioiodinated by conventional methods.
236
Clinical radioimmunotherapy—the role of radiobiology
Jean-Pierre Pouget,Isabelle Navarro-Teulon,Manuel Bardiès,Nicolas Chouin,Guillaume Cartron,André Pèlegrin,David Azria +6 more
TL;DR: An update on the current challenges aimed to improve the efficacy of radioimmunotherapy is provided and the main radiobiological issues associated with clinical radioIMmunotherapy are discussed.
227
Topoisomerase II inhibitor-related acute myeloid leukaemia.
Ching-Hon Pui,Mary V. Relling +1 more
TL;DR: The pathogenesis, clinical and biological characteristics, risk factors and treatment responsiveness of this complication are reviewed.
185
Rhenium 188–labeled anti-CD66 (a, b, c, e) monoclonal antibody to intensify the conditioning regimen prior to stem cell transplantation for patients with high-risk acute myeloid leukemia or myelodysplastic syndrome: results of a phase I-II study
Donald Bunjes,Inga Buchmann,C Duncker,Ulrike Seitz,Jörg Kotzerke,Markus Wiesneth,D. Dohr,M Stefanic,Andreas Buck,Stefanie von Harsdorf,Gerhard Glatting,Wolfgang Grimminger,Tunca Karakas,Gerd Munzert,Hartmut Döhner,Lothar Bergmann,Sven N. Reske +16 more
TL;DR: The conditioning regimen prior to stem cell transplantation in 36 patients with high-risk acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) was intensified by treating patients with a rhenium 188-labeled anti-CD66 monoclonal antibody, which provided a mean of 15.3 Gy of additional radiation to the marrow.
171
NCI First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation: Report from the Committee on Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation.
David L. Porter,Edwin P. Alyea,Joseph H. Antin,Marcos DeLima,Eli Estey,J.H. Frederik Falkenburg,Nancy M. Hardy,Nicolaus Kroeger,Jose F. Leis,John E. Levine,David G. Maloney,Karl S. Peggs,Jacob M. Rowe,Alan S. Wayne,Sergio Giralt,Michael R. Bishop,Koen van Besien +16 more
TL;DR: There is an immediate need for well-designed, disease-specific trials for treatment of relapse after alloHSCT, and recommendations are provided for specific areas of research necessary in the treatment of relapsed diseases.
156
References
Radiolabeled-antibody therapy of B-cell lymphoma with autologous bone marrow support
Oliver W. Press,Janet F. Eary,Frederick R. Appelbaum,Paul J. Martin,Christopher C. Badger,Wil B. Nelp,Stephan D. Glenn,Greg Butchko,Darrell R. Fisher,Bruce A. Porter,Dana C. Matthews,LD Fisher,Irwin D. Bernstein +12 more
TL;DR: High-dose radioimmunotherapy with 131I-labeled antibodies is associated with a high response rate in patients with B-cell lymphoma in whom antibody biodistribution is favorable.
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Radioimmunotherapy of B-Cell Lymphoma with [131I]Anti-B1 (Anti-CD20) Antibody
Mark S. Kaminski,Kenneth R. Zasadny,Isaac R. Francis,Adam W. Milik,Charles W. Ross,Scott D. Moon,Shelley M. Crawford,Jeanne M. Burgess,Neil A. Petry,Gregory Butchko,Stephan D. Glenn,Richard L. Wahl +11 more
TL;DR: Radioimmunotherapy with 131I-labeled B-cell-specific anti-CD20 monoclonal antibody in 10 patients with CD20-positive B- cell lymphomas in whom primary chemotherapy had failed is a promising new treatment for lymphoma.
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•Book
MIRD primer for absorbed dose calculations
Robert Loevinger,Thomas F. Budinger,Evelyn E. Watson +2 more
- 01 Jan 1988
594
Allogeneic marrow transplantation in patients with acute myeloid leukemia in first remission: a randomized trial of two irradiation regimens.
Reginald A. Clift,Buckner Cd,FR Appelbaum,Scott I. Bearman,Finn Bo Petersen,LD Fisher,Claudio Anasetti,Patrick G. Beatty,William I. Bensinger,Kristine Doney +9 more
TL;DR: The increased dose of TBI significantly reduced the probability of relapse but did not improve survival because of increased mortality from causes other than relapse.
578
Autologous Bone Marrow Transplantation in Patients with Acute Nonlymphocytic Leukemia, Using ex Vivo Marrow Treatment with 4-Hydroperoxycyclophosphamide
A. M. Yeager,Herbert Kaizer,George W. Santos,Rein Saral,O. Michael Colvin,Robert K. Stuart,Hayden G. Braine,Philip J. Burke,Richard F. Ambinder,William H. Burns,D. J. Fuller,J. M. Davis,Judith E. Karp,W. Stratford May,Scott D. Rowley,Lyle L. Sensenbrenner,Georgia B. Vogelsang,John R. Wingard +17 more
TL;DR: The observed disease-free survival after transplantation with autologous marrow treated with 4-hydroperoxycyclophosphamide compares favorably with the results of syngeneic or allogeneic transplantation in similar groups of patients.
453
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