Journal Article10.1345/APH.1D479
Development and Validation of the Medication Regimen Complexity Index
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TL;DR: The MRCI is a reliable and valid tool for quantifying drug regimen complexity with potential applications in both practice and research.
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Abstract: BACKGROUND:Medication regimen attributes, such as the number of drugs, dosage frequency, administration instructions, and the prescribed dosage forms, have been shown to influence patient outcomes. No single tool for quantifying the complexity of general medication regimens has been published in the medical literature.OBJECTIVE:To develop and validate a tool to quantify the complexity of prescribed medication regimens.METHODS:Literature findings and the expertise of the authors were used for developing the tool. Eight pharmacy researchers helped in establishing the tool's face and content validity. The new tool was tested on 134 medication regimens from patients with moderate to severe chronic obstructive pulmonary disease. Six regimens with a spread of scores on the tool were presented to a 5–member expert panel that subjectively ranked these regimens to confirm the tool's criterion-related validity. The relationships between scores on the tool and various independent variables were tested to judge the t...
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