Proceedings Article10.1117/12.297954
Developing optimized tissue phantom systems for optical biopsies
Gerd C. Beck,Nermin Akguen,Angelika C. Rueck,Rudolf W. Steiner +3 more
- 29 Dec 1997
- Vol. 3197, pp 76-85
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TL;DR: In this paper, the authors present a scheme by which tissue phantom systems can be designed rapidly and systematically according to individual demands, based on Mie theory, which shows that scattering and absorption of particles depends strongly on their material constants and size distribution.
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Abstract: We present a scheme by which tissue phantom systems can be designed rapidly and systematically according to individual demands. For the optical biopsies, organ structures of biological tissues have to be modeled which requires a solid host material determining the modeling potentialities. Complex structures of biological tissues can be modeled by phantom systems based on a solid host material which determines the modeling potentialities. Mie theory shows that scattering and absorption of particles depends strongly on their material constants and size distribution. According to these predictions particles can be selected or produced. Particles are not only useful to induce scattering but can also be an interesting alternative to absorbing and fluorescent dyes. We present organic, metallic and mineralic particles, their relevant properties and outlines of their characterization. We discuss how the predictions of theory and mutual interactions between components can be checked and report on problems frequently encountered with dyes and particles as components of tissue phantom systems.
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Citations
Design and Characterisation of a Tissue Phantom System for Optical Diagnostics
TL;DR: An optical phantom system especially suited to investigating the generation and transport of laser-induced fluorescence in biological tissues and in good agreement with the results of integrating sphere measurements is presented.
51
Flow cytometry with gold nanoparticles and their clusters as scattering contrast agents: FDTD simulation of light-cell interaction.
TL;DR: The validation of the FDTD approach for the simulation of flow cytometry may open up a new avenue in the development of advanced cytometric techniques based on scattering effects from nanoscale targets.
42
Patent
Testing or setting device for a PDD or PDT system, or for training on such a system and tissue phantom
Gerd Beck,André Erhardt,Klaus M. Irion +2 more
- 01 Jun 2001
TL;DR: In this paper, a tissue phantom is installed in a testing or setting device for a PDD or PDT system or for training on such a system, which includes a lighting system, provided with a housing in which the PDD/ PDT system can be at least partially accommodated.
11
Tissue image contrasting using optical immersion technique
Valery V. Tuchin
- 11 Oct 2000
TL;DR: In this article, experimental data for in vitro and in vivo studies of various solutions action on optical properties of human tissues is presented. And the possible application of refractive index matching effect for tissue imaging is discussed.
7
References
A review of the optical properties of biological tissues
TL;DR: The known optical properties (absorption, scattering, total attenuation, effective attenuation and/or anisotropy coefficients) of various biological tissues at a variety of wavelengths are reviewed in this article.
3K
An optical phantom with tissue-like properties in the visible for use in PDT and fluorescence spectroscopy
Georges Wagnières,Shangguan Cheng,Matthieu Zellweger,Nora Utke,Daniel Braichotte,Jean-Pierre Ballini,Hubert van den Bergh +6 more
TL;DR: The design and characterization of optical phantoms which have the same absorption and scattering characteristics as biological tissues in a broad spectral window (between 400 and 650 nm) are presented.
141
Phase function simulation in tissue phantoms: a fractal approach
TL;DR: In this article, the authors demonstrate that the extreme optical complexity of real biological samples can be simulated by a mixture of spheres with a fractal diameter distribution, which can be used to obtain a realistic phase function with a limited number of sphere diameters.
71
Design and Characterisation of a Tissue Phantom System for Optical Diagnostics
TL;DR: An optical phantom system especially suited to investigating the generation and transport of laser-induced fluorescence in biological tissues and in good agreement with the results of integrating sphere measurements is presented.
51
Integrating sphere effect in whole-bladder-wall photodynamic therapy: III. Fluence multiplication, optical penetration and light distribution with an eccentric source for human bladder optical properties
H J van Staveren,Marleen Keijzer,T. Keesmaat,Harald Jansen,W. Kirkel,Johan F. Beek,Willem M. Star +6 more
TL;DR: Results indicate that WBW PDT should be performed with some kind of in situ light dosimetry, and the integrating sphere effect calculated with diffusion approximation is increasingly larger than that found with MC simulations.
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