Developing and regenerating a sense of taste.
Linda A. Barlow,Ophir D. Klein +1 more
TL;DR: This review highlights new findings in the field of taste development, including how taste buds are patterned and how taste cell fate is regulated, and discusses whether a specialized taste bud stem cell population exists and how extrinsic signals can define which cell lineages are generated.
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Abstract: Taste is one of the fundamental senses, and it is essential for our ability to ingest nutritious substances and to detect and avoid potentially toxic ones. Taste buds, which are clusters of neuroepithelial receptor cells, are housed in highly organized structures called taste papillae in the oral cavity. Whereas the overall structure of the taste periphery is conserved in almost all vertebrates examined to date, the anatomical, histological, and cell biological, as well as potentially the molecular details of taste buds in the oral cavity are diverse across species and even among individuals. In mammals, several types of gustatory papillae reside on the tongue in highly ordered arrangements, and the patterning and distribution of the mature papillae depend on coordinated molecular events in embryogenesis. In this review, we highlight new findings in the field of taste development, including how taste buds are patterned and how taste cell fate is regulated. We discuss whether a specialized taste bud stem cell population exists and how extrinsic signals can define which cell lineages are generated. We also address the question of whether molecular regulation of taste cell renewal is analogous to that of taste bud development. Finally, we conclude with suggestions for future directions, including the potential influence of the maternal diet and maternal health on the sense of taste in utero.
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Citations
COVID-19 and the Chemical Senses: Supporting Players Take Center Stage.
Keiland W. Cooper,David H. Brann,Michael C. Farruggia,Surabhi Bhutani,Robert Pellegrino,Robert Pellegrino,Tatsuya Tsukahara,Caleb Weinreb,Dr. Paule V. Joseph,Eric D. Larson,Valentina Parma,Mark W. Albers,Linda A. Barlow,Sandeep Robert Datta,Antonella Di Pizio +14 more
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References
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Renewal of taste bud cells in rat circumvallate papillae.
TL;DR: The life span of taste bud cells in rat circumvallate papillae was measured by autoradiography after labeling them with a pulse of [3H]thymidine to determine the ratio of labeled cells/taste bud v. time after injection of [ 3H]TdR.
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Major taste loss in carnivorous mammals
Peihua Jiang,Jesusa Josue,Xia Li,D. Glaser,Weihua Li,Weihua Li,Joseph G. Brand,Robert F. Margolskee,Danielle R. Reed,Gary K. Beauchamp +9 more
TL;DR: The sequenced entire coding region of Tas1r2 from 12 species in the order Carnivora provided strong support for the view that loss of taste receptor function in mammals is widespread and directly related to feeding specializations.
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Electron microscope study of the developing taste bud in rat fungiform papilla.
TL;DR: An electron microscope study of the morphological sequence of events occurring in the development of the fungiform papilla and taste bud on the rat tongue has been performed, finding morphological evidence of an interaction between epithelial cells and nerve processes, an interaction which precedes differentiation of the cells into taste bud cells.
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