Journal Article10.1021/NL052396O
Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.
4.8K
TL;DR: The intracellular uptake of different sized and shaped colloidal gold nanoparticles is investigated and it is shown that kinetics and saturation concentrations are highly dependent upon the physical dimensions of the nanoparticles.
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Abstract: We investigated the intracellular uptake of different sized and shaped colloidal gold nanoparticles. We showed that kinetics and saturation concentrations are highly dependent upon the physical dimensions of the nanoparticles (e.g., uptake half-life of 14, 50, and 74 nm nanoparticles is 2.10, 1.90, and 2.24 h, respectively). The findings from this study will have implications in the chemical design of nanostructures for biomedical applications (e.g., tuning intracellular delivery rates and amounts by nanoscale dimensions and engineering complex, multifunctional nanostructures for imaging and therapeutics).
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Citations
Surface chemistry but not aspect ratio mediates the biological toxicity of gold nanorods in vitro and in vivo
TL;DR: Results demonstrated that further coating can prevent cytotoxicity and cell death upon CTAB-coated GNR administration, similar to changing the GNR aspect ratio and CTAb/PAH coated GNRs show superior biological properties with better biocompatibility and minimal cytot toxicity.
Systematic investigation of preparing biocompatible, single, and small ZnS-Capped CdSe quantum dots with amphiphilic polymers.
TL;DR: The impact of amphiphilic polymer composition on the size, transfer efficiency, and biocompatibility of tri-n-octylphosphine oxide/hexadecylamine-stabilized semiconductor ZnS- capped CdSe and CdS-capping CdTe(x)Se(1-x) quantum dots (QDs) is evaluated.
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Aiding nature's organelles: artificial peroxisomes play their role.
TL;DR: The uptake, absence of toxicity, and in situ activity in cells exposed to oxidative stress demonstrated that the artificial peroxisomes detoxify superoxide radicals and H2O2 after endosomal escape.
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Neural stem cell-mediated intratumoral delivery of gold nanorods improves photothermal therapy.
Rachael Mooney,Luella Roma,Donghong Zhao,Desiree Van Haute,Elizabeth Garcia,Seung U. Kim,Alexander J. Annala,Karen S. Aboody,Jacob M. Berlin +8 more
TL;DR: It is demonstrated that AuNR-loaded, tumor-tropic neural stem cells (NSCs) can be used to improve the intratumoral distribution of AuNRs, and that the distribution of auNRs throughout the tumors is improved when transported by NSCs, likely resulting in the improved efficacy of Au NR-loaded N SCs as compared to free Au NRs.
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Smart Gold Nanostructures for Light Mediated Cancer Theranostics: Combining Optical Diagnostics with Photothermal Therapy.
Tanveer A. Tabish,Priyanka Dey,Sara Mosca,Marzieh Salimi,Francesca Palombo,Pavel Matousek,Nicholas Stone +6 more
TL;DR: This work provides a comprehensive overview on the biological, physical and translational barriers facing the development of nanotheranostics and summarise the recent advances in engineering specific AuNPs, their unique characteristics and, importantly, tunability to achieve the desired optical/photothermal properties.
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References
Semiconductor Nanocrystals as Fluorescent Biological Labels
TL;DR: Semiconductor nanocrystals prepared for use as fluorescent probes in biological staining and diagnostics have a narrow, tunable, symmetric emission spectrum and are photochemically stable.
8.9K
Controlled nucleation for the regulation of the particle size in monodisperse gold suspensions
TL;DR: In this article, a series of monodisperse suspensions of the same chemical composition but of rather different particle sizes was used to study particle size dependent phenomena, such as Brownian motion, light scattering, sedimentation and electrophoresis of small particles.
8.4K
Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection
Warren C. W. Chan,Shuming Nie +1 more
TL;DR: Highly luminescent semiconductor quantum dots (zinc sulfide-capped cadmium selenide) have been covalently coupled to biomolecules for use in ultrasensitive biological detection and these nanometer-sized conjugates are water-soluble and biocompatible.
7.7K
Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance
Leon R. Hirsch,R.J. Stafford,James A. Bankson,S.R. Sershen,Belinda Rivera,Roger E. Price,John D. Hazle,Nancy J. Halas,Jennifer L. West +8 more
TL;DR: In vivo studies under magnetic resonance guidance revealed that exposure to low doses of NIR light in solid tumors treated with metal nanoshells reached average maximum temperatures capable of inducing irreversible tissue damage, and found good correlation with histological findings.
4.1K