Journal Article10.1021/NL052396O
Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.
4.8K
TL;DR: The intracellular uptake of different sized and shaped colloidal gold nanoparticles is investigated and it is shown that kinetics and saturation concentrations are highly dependent upon the physical dimensions of the nanoparticles.
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Abstract: We investigated the intracellular uptake of different sized and shaped colloidal gold nanoparticles. We showed that kinetics and saturation concentrations are highly dependent upon the physical dimensions of the nanoparticles (e.g., uptake half-life of 14, 50, and 74 nm nanoparticles is 2.10, 1.90, and 2.24 h, respectively). The findings from this study will have implications in the chemical design of nanostructures for biomedical applications (e.g., tuning intracellular delivery rates and amounts by nanoscale dimensions and engineering complex, multifunctional nanostructures for imaging and therapeutics).
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In vivo Gold Nanoparticle Delivery of Peptide Vaccine Induces Anti‐Tumor Immune Response in Prophylactic and Therapeutic Tumor Models
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Physical Chemistry of Nanomedicine: Understanding the Complex Behaviors of Nanoparticles in Vivo
TL;DR: This work discusses the interactions of nanoparticles with proteins, cells, tissues, and organs from a quantitative physical chemistry point of view and discusses insights and strategies on how to minimize nonspecific protein binding.
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Green Synthesis of Silver Nanoparticles Using Aqueous Citrus limon Zest Extract: Characterization and Evaluation of Their Antioxidant and Antimicrobial Properties
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TL;DR: In this paper , the green synthesis of silver nanoparticles (AgNPs) through the use of aqueous Citrus limon zest extract, optimizing the different experimental factors required for the formation and stability of AgNPs was confirmed by the observation of the color change of the mixture of silver nitrate, after the addition of the plant extract.
Surface Chemistry of Gold Nanoparticles Mediates Their Exocytosis in Macrophages
Nuri Oh,Ji-Ho Park +1 more
TL;DR: It is demonstrated that the native surface chemistries of gold nanoparticles (GNPs) and their subsequent opsonization by serum proteins play critical roles in the exocytosis patterns in macrophages, suggesting that systemic excretion and toxicity of nanoparticles cleared in the MPS could be modulated by engineering their surface chemistry.
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