Journal Article10.1021/NL052396O
Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.
4.8K
TL;DR: The intracellular uptake of different sized and shaped colloidal gold nanoparticles is investigated and it is shown that kinetics and saturation concentrations are highly dependent upon the physical dimensions of the nanoparticles.
read more
Abstract: We investigated the intracellular uptake of different sized and shaped colloidal gold nanoparticles. We showed that kinetics and saturation concentrations are highly dependent upon the physical dimensions of the nanoparticles (e.g., uptake half-life of 14, 50, and 74 nm nanoparticles is 2.10, 1.90, and 2.24 h, respectively). The findings from this study will have implications in the chemical design of nanostructures for biomedical applications (e.g., tuning intracellular delivery rates and amounts by nanoscale dimensions and engineering complex, multifunctional nanostructures for imaging and therapeutics).
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Biodistribution, Clearance, and Long‐Term Fate of Clinically Relevant Nanomaterials
Joël Bourquin,Ana Milosevic,Daniel Hauser,Roman Lehner,Fabian Blank,Alke Petri-Fink,Barbara Rothen-Rutishauser +6 more
TL;DR: Clinical relevant nanomaterials, their possible modes of exposure, as well as the biological barriers they must overcome to be effective are reviewed and the critical points that must be considered for future research are addressed.
337
Understanding nanoparticle cellular entry: A physicochemical perspective
TL;DR: It is suggested that the energetic process of NP cellular entry can be evaluated by studying the effects of NPs on lipid mesophase transitions, as the molecular deformations and thus the elastic energy cost are analogous between such transitions and endocytosis.
335
Photoluminescent diamond nanoparticles for cell labeling: study of the uptake mechanism in mammalian cells.
Orestis Faklaris,Vandana Joshi,Theano Irinopoulou,Patrick Tauc,Mohamed Sennour,Hugues A. Girard,Céline Gesset,Jean-Charles Arnault,Alain Thorel,Jean-Paul Boudou,Patrick A. Curmi,François Treussart +11 more
TL;DR: It is shown that nanodiamonds enter cells mainly by endocytosis, and converging data indicate that it is clathrin-mediated, and the results pave the way for the use of photoluminescent nanod diamonds in targeted intracellular labeling or biomolecule delivery.
332
Generation of reactive oxygen species induced by gold nanoparticles under x-ray and UV Irradiations
Masaki Misawa,Junko Takahashi +1 more
TL;DR: The radiosensitizing effect of 5-250 nm diameter Au nanoparticles in water was investigated under irradiations of diagnostic x-ray and UV light and an inverse proportion of ROS generation to the AuNPs' diameter suggests a catalytic function of AuNps' surface for enhanced ROS generation.
332
Recent advancements in biopolymer and metal nanoparticle-based materials in diabetic wound healing management.
TL;DR: This review briefed the recent development of different natural polymers and antibacterial nanoparticles to mitigate the diabetes mellitus based DFU.
330
References
Semiconductor Nanocrystals as Fluorescent Biological Labels
TL;DR: Semiconductor nanocrystals prepared for use as fluorescent probes in biological staining and diagnostics have a narrow, tunable, symmetric emission spectrum and are photochemically stable.
8.9K
Controlled nucleation for the regulation of the particle size in monodisperse gold suspensions
TL;DR: In this article, a series of monodisperse suspensions of the same chemical composition but of rather different particle sizes was used to study particle size dependent phenomena, such as Brownian motion, light scattering, sedimentation and electrophoresis of small particles.
8.4K
Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection
Warren C. W. Chan,Shuming Nie +1 more
TL;DR: Highly luminescent semiconductor quantum dots (zinc sulfide-capped cadmium selenide) have been covalently coupled to biomolecules for use in ultrasensitive biological detection and these nanometer-sized conjugates are water-soluble and biocompatible.
7.7K
Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance
Leon R. Hirsch,R.J. Stafford,James A. Bankson,S.R. Sershen,Belinda Rivera,Roger E. Price,John D. Hazle,Nancy J. Halas,Jennifer L. West +8 more
TL;DR: In vivo studies under magnetic resonance guidance revealed that exposure to low doses of NIR light in solid tumors treated with metal nanoshells reached average maximum temperatures capable of inducing irreversible tissue damage, and found good correlation with histological findings.
4.1K