Journal Article10.1152/JAPPL.1981.50.3.538
Detection of diaphragmatic fatigue in man by phrenic stimulation.
212
TL;DR: It is suggested that this long-lasting element of fatigue might occur in patients with chronic obstructive lung disease, predisposing them to respiratory failure and that diaphragmatic strength after fatigue recovers faster at high than at low frequencies of stimulation.
read more
Abstract: Transdiaphragmatic pressure (Pdi) was measured at functional residual capacity (FRC) in four normal seated subjects during supramaximal, supraclavicular transcutaneous stimulation of one phrenic nerve (10, 20, 50, and 100 Hz--0.1 ms duration) before and after diaphragmatic fatigue, produced by breathing through a high alinear inspiratory resistance. Constancy of chest wall configuration was achieved by placing a cast around the abdomen and the lower one-fourth of the rib cage. Pdi increased with frequency of stimulation, so that at 10, 20, and 50 Hz, the Pdi generated was 32 +/- 4 (SE), 70 +/- 3, and 98 +/- 2% of Pdi at 100 Hz, respectively. After diaphragmatic fatigue, Pdi was less than control at all frequencies of stimulation. Recovery for high stimulation frequencies was complete at 10 min, but at low stimulation frequencies recovery was slow: after 30 min of recovery, Pdi at 20 Hz was 31 +/- 7% of the control value. It is concluded that diaphragmatic fatigue can be detected in man by transcutaneous stimulation of the phrenic nerve and that diaphragmatic strength after fatigue recovers faster at high than at low frequencies of stimulation. Furthermore, it is suggested that this long-lasting element of fatigue might occur in patients with chronic obstructive lung disease, predisposing them to respiratory failure.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Changes in muscle contractile properties and neural control during human muscular fatigue.
B. Bigland-Ritchie,J. J. Woods +1 more
TL;DR: Evidence is presented that, in fatigue of sustained maximal voluntary contractions (MVC) executed by well‐motivated subjects, the reduction in force generating capacity need not be due to a decline in central nervous system motor drive or to failing neuromuscular transmission, but can be attributed solely to contractile failure of the muscles involved.
1K
The respiratory muscles.
Charis Roussos,Peter T. Macklem +1 more
TL;DR: A large number of patients with asthma have trouble controlling their coughing and wheezing, and the use of steroids to treat these problems is a natural application of steroids.
668
Effect of hypophosphatemia on diaphragmatic contractility in patients with acute respiratory failure
TL;DR: The results strongly suggest that hypophosphatemia impairs the contractile properties of the diaphragm during acute respiratory failure, and they emphasize the importance of maintaining normal serum inorganic phosphate levels in such patients.
488
Clinical manifestations of inspiratory muscle fatigue
TL;DR: The abnormalities of respiratory movements may be reliable clinical signs of inspiratory muscle fatigue, particularly when accompanied by tachypnea and hypercapnia.
482
Cellular Adaptations in the Diaphragm in Chronic Obstructive Pulmonary Disease
TL;DR: Severe chronic obstructive pulmonary disease increases the slow-twitch characteristics of the muscle fibers in the diaphragm, an adaptation that increases resistance to fatigue.
402