Journal Article10.1021/OP500169M
Design of Experiments (DoE) and Process Optimization. A Review of Recent Publications
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TL;DR: This review summarizes selected publications from Organic Process Research & Development using DoE to show how processes can be optimized efficiently and how DoE findings may be applied to scale-up.
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About: This article is published in Organic Process Research & Development. The article was published on 20 Nov 2015.
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Citations
High-Throughput Algorithmic Optimization of <i>In Vitro</i> Transcription for SARS-CoV-2 mRNA Vaccine Production
Spencer E. McMinn,Danielle Miller,Daniel Yur,Kevin Stone,Yuting Xu,Ajit Vikram,S Murali,Jessica Raffaele,David A. Holland,Sheng-Ching Wang,Joseph P. Smith +10 more
TL;DR: Researchers optimized in vitro transcription of SARS-CoV-2 mRNA vaccine production using machine learning and high-throughput liquid handling, achieving 12% yield improvement, 50% reaction time reduction, and 44% reagent cost decrease.
Reliability Tests as a Strategy for the Sustainability of Products and Production Processes—A Case Study
Arturo Realyvásquez-Vargas,Ramón Robles-Heredia,Jorge Luis García-Alcaraz,José Roberto Díaz-Reza +3 more
TL;DR: In this article , a case study of a manufacturing company located in Tijuana (Mexico) that produces wired and wireless communication devices is presented, where failure mode and effect analysis (FMEA), design of experiments (DOE), and analysis of variance (ANOVA) techniques are applied.
Design of experiment (D.O.E) by Taguchi model for optimization of different process parameters for LSPR system to detect VCO adulteration
TL;DR: In this paper , the authors used Localized surface plasmon resonance (LSPR) system to detect adulteration in VCO using Localized Surface Plasmon Resonance (LSR) algorithm.
Development of the crossbow-type launcher for a small reconnaissance robot based on the axiomatic theorem
TL;DR: The next generation of reconnaissance robots are being developed to be both smaller and more lightweight by implementing a two-shot crossbow-type launcher for a small reconnaissance robot based on the axiomatic theorem.
On Efficient Powder Manufacturing Using Process Control Methods and Cybernetics: A Background, Results and Policy Case Study
TL;DR: In this paper , a case study of an open-loop batch powder agglomeration process is presented, where a feedback element can be applied towards the powder manufacturing plant in order to allow for self-regulation and process optimization which, in turn, would increase process efficiency, minimize waste and ensure that the overall product quality meets production targets.
References
•Book
Statistics for experimenters
Sidney Addelman
- 01 Jan 1978
Abstract: The title compound, [Zn(C8H10F3O2)2(CH4O)2], is a dimethanol coordinated zinc complex with the acetyl acetonate derivative 1,1,1-trifluoro-5,5-dimethylhexane-2,4-dionate. The bis-β-diketonate complex, which is isostructural with its Co analogue, is located on a crystallographic inversion center. The complex is octahedral with basically no distortion, and the methanol molecules are in trans positions with respect to one another. The planes of the β-diketonate and the ZnO4 unit are tilted by 18.64 (10)° against each other. O—H⋯O hydrogen bonds between the methanol hydroxyl groups and neighboring diketonate O atoms create chains running along [100].
6.6K
Homeopathic ligand-free palladium as a catalyst in the heck reaction. A comparison with a palladacycle.
André H.M. de Vries,Jan M.C.A. Mulders,John Mommers,Huub J.W. Henderickx,Johannes G. de Vries +4 more
TL;DR: Ligand-free Pd(OAc)(2) can be used as a catalyst in the Heck reaction of aryl bromides as long as the amount of catalyst is kept between 0.01 and 0.1 mol %.
540
•Book
Design and optimization in organic synthesis
Rolf Carlson
- 05 Dec 1991
TL;DR: This work presents strategies on different levels in organic synthesis on the basis of models as tools, and a method for determining a suitable order of introducing reagents in "one-pot" procedures.
428
A reassessment of the transition-metal free suzuki-type coupling methodology.
Riina K. Arvela,Nicholas E. Leadbeater,Michael S. Sangi,Victoria A. Williams,Patricia Granados,Robert D. Singer +5 more
TL;DR: It is believed that palladium contaminants down to a level of 50 ppb found in commercially available sodium carbonate are responsible for the generation of the biaryl rather than, as previously suggested, an alternative non-palladium-mediated pathway.
360
Using Continuous Processes to Increase Production
TL;DR: This review surveys the area of continuous processes used to make larger quantities of material and discusses the feasibility of developing economical continuous operations.
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