Journal Article10.1038/NRN2150
Dendritic mRNA: transport, translation and function
Clive R. Bramham,David G. Wells +1 more
616
TL;DR: This Review attempts to integrate current knowledge of dendritic mRNA transport, storage and translation, placing particular emphasis on the coordination of regulation and function during activity-dependent synaptic plasticity in the adult mammalian brain.
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Abstract: Many cellular functions require the synthesis of a specific protein or functional cohort of proteins at a specific time and place in the cell. Local protein synthesis in neuronal dendrites is essential for understanding how neural activity patterns are transduced into persistent changes in synaptic connectivity during cortical development, memory storage and other long-term adaptive brain responses. Regional and temporal changes in protein levels are commonly coordinated by an asymmetric distribution of mRNAs. This Review attempts to integrate current knowledge of dendritic mRNA transport, storage and translation, placing particular emphasis on the coordination of regulation and function during activity-dependent synaptic plasticity in the adult mammalian brain.
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Differential regulation of mature and precursor microRNA expression by NMDA and metabotropic glutamate receptor activation during LTP in the adult dentate gyrus in vivo.
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TL;DR: This study demonstrates differential regulation of primary and mature miRNA expression by mGluR and NMDAR signaling following LTP induction, the function of which remains to be defined.
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Disrupted-in-schizophrenia 1 regulates transport of ITPR1 mRNA for synaptic plasticity
Daisuke Tsuboi,Keisuke Kuroda,Motoki Tanaka,Takashi Namba,Yukihiko Iizuka,Shinichiro Taya,Tomoyasu Shinoda,Takao Hikita,Shinsuke Muraoka,Michiro Iizuka,Ai Nimura,Akira Mizoguchi,Nobuyuki Shiina,Masahiro Sokabe,Hideyuki Okano,Katsuhiko Mikoshiba,Kozo Kaibuchi +16 more
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References
Structural basis of long-term potentiation in single dendritic spines
TL;DR: The results indicate that spines individually follow Hebb's postulate for learning and suggest that small spines are preferential sites for long-term potentiation induction, whereas large spines might represent physical traces of long- term memory.
2.5K
A brain-specific microRNA regulates dendritic spine development
Gerhard Schratt,Fabian Tuebing,Elizabeth A. Nigh,Elizabeth A. Nigh,Christina G. Kane,Christina G. Kane,Mary E. Sabatini,Michael A. Kiebler,Michael E. Greenberg,Michael E. Greenberg +9 more
TL;DR: It is shown that a brain-specific microRNA, miR-134>, is localized to the synapto-dendritic compartment of rat hippocampal neurons and negatively regulates the size of dendritic spines—postsynaptic sites of excitatory synaptic transmission.
The mGluR theory of fragile X mental retardation
TL;DR: Loss of fragile X mental retardation protein (FMRP), the defect responsible for fragile X syndrome in humans, increases LTD in mouse hippocampus, consistent with the growing evidence that FMRP normally functions as a repressor of translation of specific mRNAs.
1.6K
Translational control in stress and apoptosis
Martin Holcik,Nahum Sonenberg +1 more
TL;DR: Two representative models are examined, the regulation of eukaryotic initiation factor-2α by phosphorylation and internal ribosome initiation through the internal Ribosome-entry site, which illustrate the importance of translational control in the cellular stress response and apoptosis.
1.4K
Altered synaptic plasticity in a mouse model of fragile X mental retardation
TL;DR: It is shown that a form of protein synthesis-dependent synaptic plasticity, long-term depression triggered by activation of metabotropic glutamate receptors, is selectively enhanced in the hippocampus of mutant mice lacking FMRP.
1.3K