Journal Article10.1038/NRN2150
Dendritic mRNA: transport, translation and function
Clive R. Bramham,David G. Wells +1 more
616
TL;DR: This Review attempts to integrate current knowledge of dendritic mRNA transport, storage and translation, placing particular emphasis on the coordination of regulation and function during activity-dependent synaptic plasticity in the adult mammalian brain.
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Abstract: Many cellular functions require the synthesis of a specific protein or functional cohort of proteins at a specific time and place in the cell. Local protein synthesis in neuronal dendrites is essential for understanding how neural activity patterns are transduced into persistent changes in synaptic connectivity during cortical development, memory storage and other long-term adaptive brain responses. Regional and temporal changes in protein levels are commonly coordinated by an asymmetric distribution of mRNAs. This Review attempts to integrate current knowledge of dendritic mRNA transport, storage and translation, placing particular emphasis on the coordination of regulation and function during activity-dependent synaptic plasticity in the adult mammalian brain.
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Molecular motors: directing traffic during RNA localization
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The Me31B DEAD-Box Helicase Localizes to Postsynaptic Foci and Regulates Expression of a CaMKII Reporter mRNA in Dendrites of Drosophila Olfactory Projection Neurons
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•Dissertation
Synaptic Specificity and Plasticity in Parvalbumin-Basket Cell Circuits
Luke Joseph Bogart
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New Insights Into the Role of Cav2 Protein Family in Calcium Flux Deregulation in Fmr1-KO Neurons.
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TL;DR: A new phenotype of cultured Fmr1-KO neurons is highlighted that can be considered a novel cellular biomarker and is amenable to small molecule screening and identification of new drugs to treat FXS.
Dendrites as separate compartment – local protein synthesis [Review]
Małgorzata Skup
TL;DR: Local protein synthesis in dendrites provides the basis for rapid changes in synaptic strength and synaptic plasticity.
References
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TL;DR: The results indicate that spines individually follow Hebb's postulate for learning and suggest that small spines are preferential sites for long-term potentiation induction, whereas large spines might represent physical traces of long- term memory.
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TL;DR: It is shown that a brain-specific microRNA, miR-134>, is localized to the synapto-dendritic compartment of rat hippocampal neurons and negatively regulates the size of dendritic spines—postsynaptic sites of excitatory synaptic transmission.
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