Journal Article10.1038/359641A0
Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction.
François Cambien,Odette Poirier,Laure Lecerf,Alun Evans,Jean-Pierre Cambou,Dominique Arveiler,Gérald Luc,Jean-Marie Bard,L Bara,Sylvain Ricard +9 more
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TL;DR: It is reported that the DD genotype, which is associated with higher levels of circulating ACE than the ID and II genotypes, is significantly more frequent in patients with myocardial infarction than in controls, especially among subjects with low body-mass index and low plasma levels of ApoB.
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Abstract: Factors involved in the pathogenesis of atherosclerosis, thrombosis and vasoconstriction contribute to the development of coronary heart disease. In a study comparing patients after myocardial infarction with controls, we have explored a possible association between coronary heart disease and a variation found in the gene encoding angiotensin-converting enzyme (ACE). The polymorphism ACE/ID is strongly associated with the level of circulating enzyme. This enzyme plays a key role in the production of angiotensin II and in the catabolism of bradykinin, two peptides involved in the modulation of vascular tone and in the proliferation of smooth muscle cells. Here we report that the DD genotype, which is associated with higher levels of circulating ACE than the ID and II genotypes, is significantly more frequent in patients with myocardial infarction (n = 610) than in controls (n = 733) (P = 0.007), especially among subjects with low body-mass index and low plasma levels of ApoB (P < 0.0001). The ACE/ID polymorphism seems to be a potent risk factor of coronary heart disease in subjects formerly considered to be at low risk according to common criteria.
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Citations
Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice
Masao Kakoki,Kelli A. Sullivan,Carey Backus,John M. Hayes,Sang Su Oh,Kunjie Hua,Adil Gasim,Hirofumi Tomita,Ruriko Grant,Sarah B. Nossov,Hyung Suk Kim,J. Charles Jennette,Eva L. Feldman,Oliver Smithies +13 more
TL;DR: The influence of lack of both bradykinin receptors (B1R and B2R) on diabetic nephropathy, neuropathy, and osteopathy in male mice heterozygous for the Akita diabetogenic mutation in the insulin 2 gene is explored.
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Deletion Polymorphism of the Angiotensin I-Converting Enzyme Gene Is Associated with Increased Plasma Angiotensin-Converting Enzyme Activity but Not with Increased Risk for Myocardial Infarction and Coronary Artery Disease
Winkelmann Br,Markus Nauck,B. Klein,A.P. Russ,B. Böhm,Siekmeier R,Kai Ihnken,Verho M,W Gross,Winfried März +9 more
TL;DR: A large number of men who were born in 1927 or later, had recently had coronary angiography, and were scheduled for coronary bypass surgery or open-heart surgery not related to the coronary arteries at the Department of Cardiothoracic Surgery, Frankfurt University were eligible for the study.
115
Association between the angiotensin-converting enzyme-insertion/deletion polymorphism and diabetic nephropathy: a methodologic appraisal and systematic review.
TL;DR: This analysis fails to confirm an association between the ACE-insertion/deletion genotype and nephropathy in Caucasians with NIDDM or IDDM, but a role for this genetic marker in Asian patients cannot be ruled out.
•Journal Article
Segregation and linkage analysis of serum angiotensin I-converting enzyme levels: evidence for two quantitative-trait loci.
Colin A. McKenzie,C Julier,Terrence Forrester,Norma McFarlane-Anderson,Bernard Keavney,G.M. Lathrop,Peter J. Ratcliffe,Martin Farrall +7 more
TL;DR: It is concluded that two QTLs jointly influence serum ACE levels in this population and the identification of the molecular mechanisms underlying bothQTLs is necessary in order to interpret the role of ACE in cardiovascular disease.
115
Deletion-type allele of the angiotensin-converting enzyme gene is associated with progressive ventricular dilation after anterior myocardial infarction
TL;DR: This exploratory study suggests that homozygosity for the angiotensin-converting enzyme deletion-type allele is associated with augmented neurohumoral activation as well as augmented cardiac dilation after an acute anterior myocardial infarction, an effect that may be susceptible to angiotENSin- Converting enzyme inhibition.
114
References
An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels.
TL;DR: The insertion/deletion polymorphism accounted for 47% of the total phenotypic variance of serum ACE, showing that the ACE gene locus is the major locus that determines serum ACE concentration.
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•Journal Article
Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels.
Laurence Tiret,B Rigat,Sophie Visvikis,C Breda,Pierre Corvol,François Cambien,Florent Soubrier +6 more
TL;DR: A combined segregation and linkage analysis provided evidence that the major-gene effect was due to a variant of the ACE gene, in strong linkage disequilibrium with the I/D polymorphism.
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