Journal Article10.1038/359641A0
Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction.
François Cambien,Odette Poirier,Laure Lecerf,Alun Evans,Jean-Pierre Cambou,Dominique Arveiler,Gérald Luc,Jean-Marie Bard,L Bara,Sylvain Ricard +9 more
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TL;DR: It is reported that the DD genotype, which is associated with higher levels of circulating ACE than the ID and II genotypes, is significantly more frequent in patients with myocardial infarction than in controls, especially among subjects with low body-mass index and low plasma levels of ApoB.
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Abstract: Factors involved in the pathogenesis of atherosclerosis, thrombosis and vasoconstriction contribute to the development of coronary heart disease. In a study comparing patients after myocardial infarction with controls, we have explored a possible association between coronary heart disease and a variation found in the gene encoding angiotensin-converting enzyme (ACE). The polymorphism ACE/ID is strongly associated with the level of circulating enzyme. This enzyme plays a key role in the production of angiotensin II and in the catabolism of bradykinin, two peptides involved in the modulation of vascular tone and in the proliferation of smooth muscle cells. Here we report that the DD genotype, which is associated with higher levels of circulating ACE than the ID and II genotypes, is significantly more frequent in patients with myocardial infarction (n = 610) than in controls (n = 733) (P = 0.007), especially among subjects with low body-mass index and low plasma levels of ApoB (P < 0.0001). The ACE/ID polymorphism seems to be a potent risk factor of coronary heart disease in subjects formerly considered to be at low risk according to common criteria.
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Citations
Biochemistry and cell biology of angiotensin-converting enzyme and converting enzyme inhibitors.
Kathleen H. Berecek,Lin Zhang +1 more
TL;DR: Most of the conversion of circulating AI to AII occurs during passage through the lungs, but this dipeptidyl carboxypeptidase has been found to be widely distributed throughout the body as a membrane bound ectoenzyme on the surface of vascular endothelial cells and epithelial cells of many organs.
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Association of CILP2 and ACE Gene Polymorphisms with Cardiovascular Risk Factors in Slovak Midlife Women
TL;DR: The results of this study suggest that the minor T allele of CILP2 gene and I allele of ACE gene have a protective effect against elevated serum lipid and lipoprotein levels.
The angiotensin converting enzyme gene in cardiovascular disease.
TL;DR: The concept of an association between a gene encoding a component of the renin angiotensin system and a cardiac disease phenotype is particularly attractive in view of the accumulating evidence that ACE inhibition reduces morbidity and mortality from left ventricular dysfunction.
14
References
An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels.
TL;DR: The insertion/deletion polymorphism accounted for 47% of the total phenotypic variance of serum ACE, showing that the ACE gene locus is the major locus that determines serum ACE concentration.
The pathogenesis of coronary artery disease and the acute coronary syndromes (1).
TL;DR: The two hypotheses to explain the pathogenesis of atherosclerosis, the "incrustation" hypothesis and the "lipid" hypothesis, are now known.
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•Journal Article
Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels.
Laurence Tiret,B Rigat,Sophie Visvikis,C Breda,Pierre Corvol,François Cambien,Florent Soubrier +6 more
TL;DR: A combined segregation and linkage analysis provided evidence that the major-gene effect was due to a variant of the ACE gene, in strong linkage disequilibrium with the I/D polymorphism.
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