Delayed regional lymph node dissection in stage I melanoma of the skin of the lower extremities
Umberto Veronesi,Jerzy Adamus,D. C. Bandiera,I. O. Brennhovd,Eduardo Caceres,Natale Cascinelli,F. Claudio,R. L. Ikonopisov,V. V. Javorski,S. Kirov,A. Kulakowski,Jean Lacour,Ferdinand Lejeune,Z. Mechl,Alberto Morabito,I. Rodé,S. Sergeev,E. van Slooten,K. Szczygiel,N. N. Trapeznikov,R. I. Wagner +20 more
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TL;DR: The authors conclude that delayed node dissection is as effective as the immediate dissection in Stage I melanoma of the extremities if the patient can be checked every three months and if the quarterly follow‐up is not guaranteed.
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Abstract: Results of a prospective randomized clinical trial conducted by the WHO Collaborating Centers for the Evaluation of Methods of Diagnosis and Treatment of Melanoma are reported. Five-hundred-fifty-three Stage I patients whose limbs were affected entered the study; 267 were submitted to wide excision and immediate node dissection and 286 had wide excision and node dissection at the time clinically positive nodes were detected. Survival curves of the two treatment groups could be superimposed. No subsets of patients benefitted from immediate node dissection. The authors conclude that delayed node dissection is as effective as the immediate dissection in Stage I melanoma of the extremities if the patient can be checked every three months. If the quarterly follow-up is not guaranteed, immediate node dissection is advisable, at least for melanomas thicker than 2 mm.
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Malignant melanoma of the skin. I. The association of tumor depth and type, and patient sex, age, and site with survival.
Marsden S. Blois,Marsden S. Blois,Richard W. Sagebiel,Richard W. Sagebiel,Robert M. Abarbanel,Taylor M. Caldwell,Mark S. Tuttle,Mark S. Tuttle +7 more
TL;DR: Evidence is presented that sex, tumor location, and age (in the case of males) are also predictive of survival and associated with prognoses and survivals.
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TL;DR: Evidence is presented suggesting that superficial spreading melanoma and lentigo maligna melanoma (Hutchinson9s melanotic freckle) show a long period of superficial growth, followed by the relatively rapid appearance of nodules or deeper invasion within the primary lesion.
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Inefficacy of Immediate Node Dissection in Stage 1 Melanoma of the Limbs
Umberto Veronesi,Jerzy Adamus,D. C. Bandiera,I. O. Brennhovd,E. Caceres,Natale Cascinelli,F. Claudio,R. L. Ikonopisov,V. V. Javorskj,S. Kirov,A. Kulakowski,Lacoub J,Ferdy J. Lejeune,Z. Mechl,Alberto Morabito,I. Rodé,S. Sergeev,van Slooten E,Szcygiel K,N. N. Trapeznikov +19 more
TL;DR: Elective lymph-node dissection in malignant malanoma of the limbs does not improve the prognosis and is not recommended when patients can be followed at intervals of three months.
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Tumor thickness, level of invasion and node dissection in stage I cutaneous melanoma.
TL;DR: It was found that tumor thickness is a better measure of prognosis than is the level of invasion of the tumor, and the chance of developing recurrent disease appears to be directly proportional to tumor thickness.
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Selection of the optimum surgical treatment of stage I melanoma by depth of microinvasion: Use of the combined microstage technique (Clark-Breslow).
Harold J. Wanebo,Joseph G. Fortner,James M. Woodruff,Barbara J. Maclean,B. S. Edward Binkowski +4 more
TL;DR: There is suggestive evidence that patients with certain higher risk lesions may do significantly better with wide excision and elective node dissection than withWide excision alone and all nodular melanomas.
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