Degree of synovitis on MRI by comprehensive whole knee semi-quantitative scoring method correlates with histologic and macroscopic features of synovial tissue inflammation in knee osteoarthritis

TL;DR: Lifespan analyses suggest that, in the absence of well powered longitudinal studies, the ENIGMA cross-sectional sample across six decades of ages provides a means to generate hypotheses about lifespan trajectories in brain phenotypes.

TL;DR: Current knowledge on the prevalence of synovial inflammation in OA and its role in symptoms and structural progression is reviewed, and lessons learnt from targeting synovitis therapeutically are explored.

TL;DR: Bioenergy-sensing by AMPK and SIRT1 provides 'stop signals' for oxidative stress, inflammatory, and matrix catabolic processes in chondrocytes, raising daunting questions about how to therapeutically target inflammatory processes and macroscopic inflammation in OA.

TL;DR: In this article , the authors examined the biology of synovial inflammation, the cell types involved, their interactions and the role of Synovitis in the development and progression of osteoarthritis.

TL;DR: As synovitis is associated with clinical symptoms and also reflects joint degradation in OA, synovium-targeted therapy could help alleviate the symptoms of the disease and perhaps also prevent structural progression.

TL;DR: Increased mononuclear cell infiltration and overexpression of mediators of inflammation were seen in early OA, compared with late OA; these observations may have important therapeutic implications for some patients during the early evolution of OA

TL;DR: A 66-year-old woman who is overweight reports bilateral knee pain of gradual onset during the past several months that increasingly has limited her activities and last week, when walking down the stairs, she nearly fell when her knee gave way.

TL;DR: Chronic inflammatory changes with production of proinflammatory cytokines are a feature of synovial membranes from patients with early OA, with the most severe changes seen in patients at the time of joint replacement surgery resembling those seen in rheumatoid arthritis.