Journal Article10.1038/13590
Defining epitopes: It's not as easy as it seems.
Neil S. Greenspan,Di Cera E +1 more
492
About: This article is published in Nature Biotechnology. The article was published on 01 Oct 1999.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Patent
Methods of preparing antibody-active agent conjugates
Yongzu Kim,Taekyo Park,Sung Ho Woo,Hyang Sook Lee,Kim Sunyoung,Cho Jongun,Doo Hwan Jung,Youngun Kim,Hyun Jin Kwon,Kyu Man Oh,Yunseo Chung,Park Yun-Hee +11 more
- 15 Feb 2014
TL;DR: In this article, the authors presented methods for preparing an antibody-active agent conjugate, consisting of an antibody, a cysteine residue of an amino acid motif that can be recognized by an isoprenoid transferase located at or after the carboxy-terminus of the antibody, and an active agent.
Patent
Methods of inducing an immune response with compositions comprising a neisseria meningitidis 741 protein
Mariagrazia Pizza
- 16 Jun 2014
TL;DR: In this article, two or more Neisserial proteins are joined such that they are translated as a single polypeptide chain, represented by the formula NH 2 -A-[-X-L-] n -B-COOH where X is an amino acid sequence, L is an optional linker sequence, and n is an integer greater than 1.
Patent
Antibodies against human FZD5 and FZD8
Austin L. Gurney,Aaron K. Sato,Fumiko Takada Axelrod,Timothy Hoey,Sanjeev Satyal,Satyajit Sujit Kumar Mitra +5 more
- 26 Jan 2015
TL;DR: In this article, novel epitopes within the human frizzled receptors which are suitable as targets for anti-cancer agents are also identified, and methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided.
Protein thermodynamics and the cognitive ecology of biomedicine.
TL;DR: The process for assigning credit for research advances to individual researchers might benefit from emulating this thermodynamic thought process by recognizing that contributions of equal quantitative significance can be of different types and can originate through indirect effects.
Patent
Hpv types and variants associated with cervical cancer and the uses thereof
W. G. V. Quint,Maurits Nicolaas Cornelis De Koning,D.T. Geraets,Leendert Jan Van Doorn,Silvia De Sanjose Llongueras,Francisco Javier Bosch +5 more
- 12 Nov 2009
TL;DR: In this article, the authors proposed a method for identification of novel sequences associated with cervical cancer, probes and kits for the identification of said sequences, and vaccines suitable for vaccination against new cancer causing HPV types.
References
A hot spot of binding energy in a hormone-receptor interface
Tim Clackson,James A. Wells +1 more
TL;DR: The x-ray crystal structure of the complex between human growth hormone and the extracellular domian of its first bound receptor (hGHbp) shows that about 30 side chains from each protein make contact, which resembles a cross section through a globular protein.
2K
High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis.
TL;DR: The overall folding of these mutant proteins was indistinguishable from that of the wild-type hGH, as determined by strong cross-reactivities with seven different conformationally sensitive monoclonal antibodies.
1.9K
The interaction of thrombin with fibrinogen. A structural basis for its specificity.
Milton T. Stubbs,Hartmut Oschkinat,Irmgard Mayr,Robert Huber,Herbert Angliker,Stuart R. Stone,Wolfram Bode +6 more
TL;DR: The surface topology of the thrombin molecule indicates positions P1'-P3', differ from those of the canonical serine-proteinase inhibitors, suggesting a mechanical model for the switching ofThrombin activity from fibrinogen cleavage to protein-C activation on thrombomodulin complex formation.
222
From absolute to exquisite specificity. Reflections on the fuzzy nature of species, specificity and antigenic sites.
TL;DR: The term specificity is derived from the word species and shares with it an inherent fuzziness based on the absence of sharp boundaries between closely related entities and this poses no threat to the unabated further development of immunochemical analysis.
107
Rational engineering of activity and specificity in a serine protease
TL;DR: It is demonstrated that rational site-directed mutagenesis of residues controlling Na+ binding can profoundly alter the properties of a serine protease, and by suppressing Na+binding to thrombin, the balance between procoagulant and anticoagulants activities of the enzyme is shifted.
105