Defining epitopes: It's not as easy as it seems.

TL;DR: In this paper, compositions and methods of use of anti-pancreatic cancer antibodies or fragments thereof, such as murine, chimeric, humanized or human PAM4 antibodies show novel and useful diagnostic characteristics.

TL;DR: In this paper, the authors described compositions and methods of using anti-epidermal growth factor (EGFR) antibodies and antibody drug conjugates (ADCs), including compositions and method of using said antibodies and ADCs.

TL;DR: The three dimensional localization of this epitope and its differential exposure in active and latent forms of PAI-1 provide a molecular explanation for the underlying mechanism of MA-33B8.

TL;DR: The overall folding of these mutant proteins was indistinguishable from that of the wild-type hGH, as determined by strong cross-reactivities with seven different conformationally sensitive monoclonal antibodies.

TL;DR: The surface topology of the thrombin molecule indicates positions P1'-P3', differ from those of the canonical serine-proteinase inhibitors, suggesting a mechanical model for the switching ofThrombin activity from fibrinogen cleavage to protein-C activation on thrombomodulin complex formation.

TL;DR: The term specificity is derived from the word species and shares with it an inherent fuzziness based on the absence of sharp boundaries between closely related entities and this poses no threat to the unabated further development of immunochemical analysis.

TL;DR: It is demonstrated that rational site-directed mutagenesis of residues controlling Na+ binding can profoundly alter the properties of a serine protease, and by suppressing Na+binding to thrombin, the balance between procoagulant and anticoagulants activities of the enzyme is shifted.