Journal Article10.1007/S00259-002-0818-1
Decreased endothelium-dependent coronary vasomotion in healthy young smokers.
Yasuyoshi Iwado,Keiichiro Yoshinaga,Hideto Furuyama,Yoshinori Ito,Kazuyuki Noriyasu,Chietsugu Katoh,Yuji Kuge,Eriko Tsukamoto,Nagara Tamaki +8 more
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TL;DR: Endothelium-dependent coronary artery vasodilator function is impaired in apparently healthy young smokers and the ratio of CPT MBF to resting MBF was inversely correlated with pack-years.
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Abstract: Chronic cigarette smoking alters coronary vascular endothelial response. To determine whether altered response also occurs in young individuals without manifest coronary disease we quantified coronary blood flow at rest, following adenosine vasodilator stress and during the cold pressor test in healthy young smokers. Myocardial blood flow (MBF) was quantified by oxygen-15 labelled water positron emission tomography in 30 healthy men aged from 20 to 35 years (18 smokers and 12 non-smokers, aged 27.4 +/- 4.4 vs 26.3 +/- 3.3). The smokers had been smoking cigarettes for 9.4 +/- 4.9 pack-years. MBF was measured at rest, during intravenous adenosine triphosphate (ATP: 0.16 mg kg(-1) min(-1)) infusion (hyperaemic response), and during cold pressor test (CPT) (endothelial vasodilator response). Rest MBF and hyperaemic MBF did not differ significantly between the smokers and the non-smokers (rest: 0.86 +/- 0.11 vs 0.92 +/- 0.14 and ATP: 3.20 +/- 1.12 vs 3.69 +/- 0.76 ml g(-1) min(-1); P = NS). Coronary flow reserve was similar between the two groups (smokers: 3.78 +/- 1.83; non-smokers: 4.03 +/- 0.68; P = NS). Although CPT induced a similar increase in rate-pressure product (RPP) in the smokers and the non-smokers (10,430 +/- 1,820 vs 9,236 +/- 1,356 beats min(-1) mmHg(-1)), CPT MBF corrected by RPP was significantly decreased in the smokers (0.65 +/- 0.12 ml g(-1) min(-1)) compared with the non-smokers (0.87 +/- 0.12 ml g(-1) min(-1)) ( P < 0.05). In addition, the ratio of CPT MBF to resting MBF was inversely correlated with pack-years ( r = -0.57, P = 0.014). Endothelium-dependent coronary artery vasodilator function is impaired in apparently healthy young smokers.
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Citations
Improved Cardiac Risk Assessment With Noninvasive Measures of Coronary Flow Reserve
Venkatesh L. Murthy,Masanao Naya,Courtney Foster,Jon Hainer,Mariya Gaber,Gilda Di Carli,Ron Blankstein,Sharmila Dorbala,Arkadiusz Sitek,Michael J. Pencina,Marcelo F. Di Carli +10 more
TL;DR: Noninvasive quantitative assessment of coronary vasodilator function with positron emission tomography is a powerful, independent predictor of cardiac mortality in patients with known or suspected coronary artery disease and provides meaningful incremental risk stratification over clinical and gated myocardial perfusion imaging variables.
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Preserved Coronary Flow Reserve Effectively Excludes High-Risk Coronary Artery Disease on Angiography
Masanao Naya,Venkatesh L. Murthy,Venkatesh L. Murthy,Viviany R. Taqueti,Courtney Foster,Josh Klein,Mariya Garber,Sharmila Dorbala,Jon Hainer,Ron Blankstein,Frederick Resnic,Marcelo F. Di Carli +11 more
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191
Coronary risk factors and myocardial perfusion in asymptomatic adults: the Multi-Ethnic Study of Atherosclerosis (MESA).
Lu Wang,Michael Jerosch-Herold,Michael Jerosch-Herold,David R. Jacobs,David R. Jacobs,Eyal Shahar,Aaron R. Folsom +6 more
TL;DR: Coronary vasoreactivity is reduced in asymptomatic individuals with a greater coronary risk factor burden, implying that changes in coronary vascular reactivity, in response to risk factors, may be detected in adults without symptomatic CHD.
138
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