Journal Article10.1016/S0006-291X(82)80157-5
Decrease of transferrin receptor during mouse myeloid leukemia (Ml) cell differentiation
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TL;DR: The binding of 125 I-labeled transferrin to the cells began to decline after 8 hr of dexamethasone treatment and reached to about one-third that of the non-treated cells at fully differentiated stage, similar to the differentiation associated decline of DNA synthesis.
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About: This article is published in Biochemical and Biophysical Research Communications. The article was published on 31 Aug 1982. The article focuses on the topics: Transferrin receptor & Transferrin.
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Citations
Transferrin receptors in rat brain: neuropeptide-like pattern and relationship to iron distribution
TL;DR: The characterized and visualized the binding of 125I-labeled transferrin to sections of rat brain and the pattern of transferrin receptor distribution suggests that transferrin may have neuromodulatory, perhaps behavioral, function in brain.
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The 1985 Walter Hubert lecture. Malignant cell differentiation as a potential therapeutic approach.
TL;DR: To study the phenomenon of blocked maturation, squamous carcinoma SqCC/Y1 cells were employed in culture and it was possible to demonstrate that physiological levels of retinoic acid and epidermal growth factor were capable of preventing the differentiation of these malignant keratinocytes into a mature tissue-like structure.
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The role of iron in tumour cell proliferation
TL;DR: The current scientific evidence behind iron’s role as a protumoral agent, and the potential benefit of a state of iron depletion in patients with cancer are reviewed.
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Cell proliferation and expression of the transferrin receptor gene: promoter sequence homologies and protein interactions.
TL;DR: A 365-bp fragment from the 5' region of the human transferrin receptor gene has been subcloned and sequenced and contains a TATA box, several GC-rich regions, and is able to efficiently promote expression of the bacterial CAT gene in mouse 3T3 cells.
•Journal Article
Inhibition of Glycoprotein Biosynthesis by the Inducers of HL-60 Cell Differentiation, Aclacinomycin A and Marcellomycin
TL;DR: Findings demonstrate a new biochemical site of action for ACM and MCM and suggest that this activity is involved in the induction of terminal differentiation of HL-60 leukemia cells by these antitumor agents.
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References
Fractionation of a Differentiated Mouse Leukemia Cell Line by Discontinuous Ficoll-Urografin Density Gradients
TL;DR: Elevated lysosomal enzyme activity in the highest density fraction of the fractionated cells indicates that these cells may differ from M1 cells in their biological activity.
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Close Association of Mouse Myeloid Leukemia (M1) Cell Differentiation with Cessation of DNA Synthesis
TL;DR: Results indicate that M1 cell differentiation is closely coupled with the cessation of DNA synthesis, and shows that the DNA synthesis of the differentiat-ed cells declined with the decreased density, or ratio of nucleus size to cell size (N/C ratio).
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