Journal Article10.1016/S0006-291X(82)80157-5
Decrease of transferrin receptor during mouse myeloid leukemia (Ml) cell differentiation
24
TL;DR: The binding of 125 I-labeled transferrin to the cells began to decline after 8 hr of dexamethasone treatment and reached to about one-third that of the non-treated cells at fully differentiated stage, similar to the differentiation associated decline of DNA synthesis.
read more
About: This article is published in Biochemical and Biophysical Research Communications. The article was published on 31 Aug 1982. The article focuses on the topics: Transferrin receptor & Transferrin.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
The regulation of the transferrin receptor by inducers of cellular differentiation and by antisense phosphorothioate oligodeoxynucleotides
Peter Tai-Ching Ho
- 01 Jan 1990
TL;DR: The TfR appears to be an important component of the genetic changes underlying leukemic cell differention; however, its precise role within this framework of cellular mediators and processes critical to the maturation process remains to be fully elucidated.
Proteome Analysis of Adult Acute Lymphoblastic Leukemia by Two-dimensional Blue Native/Sodium Dodecyl Sulfate Gel Electrophoresis
Servin Bagheralmoosavi,Parasto Gholami,Mahdi Amini,M. Alizadeh,Marjan Yaghmaei,S. J. Tavakkoli,Sina Salari,Mahmood Jeddi-Tehrani,Alireza Ghasempour,Kambiz Gilany,Mahdi Shabani +10 more
TL;DR: In this article , the cell membrane proteome of peripheral blood mononuclear cells of adult B-ALL patients in comparison to that of the healthy controls was analyzed using 2-dimensional blue-native SDS-PAGE technique followed by MALDI-TOF/TOF-mass spectrometry.
Serum-Free Cultures: Could They Be a Future Direction to Improve Neuronal Differentiation of Mesenchymal Stromal Cells?
TL;DR: Experimental studies that demonstrate that serum-free cultures, along with the supplementation of growth factors or chemicals, can lead to a more defined and controlled environment, enhancing the proliferation and neuronal differentiation of MSCs are provided.
“Humanized” Stem Cell Culture Techniques: The Animal Serum Controversy
TL;DR: The various caveats associated with conventionally used supplements of xenogenic origin are outlined and the possible alternatives/additives which could one day herald the dawn of a new era in the translation of in vitro cultured cells to therapeutic interventions are portrayed.
References
Control of normal cell differentiation and the phenotypic reversion of malignancy in myeloid leukaemia
TL;DR: A cell system has been developed to determine and dissect the controls that regulate normal myeloids cell growth, differentiation and malignancy, and to suggest a novel approach to the therapy of myeloid leukaemia.
619
Modulation of cell surface iron transferrin receptors by cellular density and state of activation.
James W. Larrick,Peter Cresswell +1 more
TL;DR: Investigations of plasma membrane transferring receptors on a variety of lymphoid cell lines and normal peripheral blood lymphocytes during activation and cell growth cycles anticipate nuclear changes during cell activation and subsequent mitosis of normal cells.
376
Isolation and characterization of the transferrin receptor from human placenta.
TL;DR: The isolated receptor is immunologically related to the transferrin receptor on the reticulocyte cell surface and has a Mr = 90,000 on sodium dodecyl sulfate-gel electrophoresis in the presence of 2-mercaptoethanol.
218
Demonstration of the transferrin receptor in human breast cancer tissue. Potential marker for identifying dividing cells.
TL;DR: A transferrin receptor was demonstrated in tumor tissue from 10 patients with breast carcinoma and one patient with breast sarcoma, and scatchard analysis of binding studies indicate that the receptor has a Ka = 9.0 × 108M site, specific for transferrin.
205