Journal Article10.1016/j.jphotobiol.2024.112928
Decrease of ESKAPE virulence with a cationic heme-mimetic gallium porphyrin photosensitizer: The Trojan horse strategy that could help address antimicrobial resistance.
Klaudia Szymczak,Agata Woźniak-Pawlikowska,Natalia Burzyńska,Magdalena Król,Lei Zhang,Joanna Nakonieczna,Mariusz Grinholc +6 more
- 01 May 2024
Vol. 256, pp 112928-112928
TL;DR: A cationic heme-mimetic gallium porphyrin photosensitizer suppresses virulence in ESKAPE pathogens, offering a non-antibiotic strategy to combat antibiotic-resistant infections by targeting multiple virulence traits, a promising approach to address antimicrobial resistance.
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Abstract: Emerging antibiotic resistance among bacterial pathogens has forced an urgent need for alternative non-antibiotic strategies development that could combat drug resistant-associated infections. Suppression of virulence of ESKAPE pathogens' by targeting multiple virulence traits provides a promising approach.
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