Journal Article10.1046/J.1365-2559.2003.01719.X
Decrease of Deleted in Malignant Brain Tumour-1 (DMBT-1) expression is a crucial late event in intrahepatic cholangiocarcinoma
Motoko Sasaki,Huang Sf,M.-F. Chen,Yi-Yin Jan,Ta-Sen Yeh,Akira Ishikawa,Akira Ishikawa,Jan Mollenhauer,Annemarie Poustka,Koichi Tsuneyama,Yuji Nimura,Koji Oda,Yasuni Nakanuma +12 more
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TL;DR: To investigate the participation of DMBT‐1, a candidate tumour suppressor gene, in the development of intrahepatic cholangiocarcinoma via intraductal papillary neoplasm of the liver (IPN‐L) arising in hepatolithiasis.
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Abstract: Aims: To investigate the participation of DMBT-1, a candidate tumour suppressor gene, in the development of intrahepatic cholangiocarcinoma via intraductal papillary neoplasm of the liver (IPN-L) arising in hepatolithiasis. DMBT-1 plays a role in mucosal immune defence.
Methods and results: The expression of DMBT-1 was examined immunohistochemically in biliary epithelial cells in hepatolithiasis (n = 25), invasive and non-invasive cholangiocarcinoma associated with hepatolithiasis (n = 52), IPN-L with hepatolithiasis (n = 49), cholangiocarcinoma without hepatolithiasis (n = 32), and 10 normal control livers. DMBT-1 was expressed more frequently in the biliary epithelia of hepatolithiasis when compared with normal livers (P < 0.05). DMBT-1 expression was also frequent in IPN-L (57%) and non-invasive cholangiocarcinoma (79%). By contrast, DMBT-1 was decreased in invasive cholangiocarcinoma with and without hepatolithiasis (50% and 30%, respectively) (P < 0.05). The homozygous deletion of the DMBT-1 gene was recognized in four (20%) of 20 cholangiocarcinoma tissues and two (50%) of four cholangiocarcinoma cell lines, corresponding to the reduction of DMBT-1 expression. No deletion was detected in hepatolithiasis tissues.
Conclusion: DMBT-1 expression is increased in IPN-L and non-invasive cholangiocarcinoma as well as in biliary epithelia in hepatolithiasis. Decreased expression of DMBT-1 and homozygous deletion of the DMBT-1 gene in invasive cholangiocarcinoma suggest that they occur in the late stage of cholangiocarcinogenesis.
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Expression of deleted in malignant brain tumours 1 (DMBT1) relates to the proliferation and malignant transformation of hepatic progenitor cells in hepatitis B virus-related liver diseases.
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References
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DMBT1 encodes a protein involved in the immune defense and in epithelial differentiation and is highly unstable in cancer.
Jan Mollenhauer,Stephan Herbertz,Uffe Holmskov,Markus Tolnay,Inge Krebs,Adrian Merlo,Henrik Daa Schrøder,Daniel Maier,Frank Breitling,Stefan Wiemann,Hermann Josef Gröne,Annemarie Poustka +11 more
TL;DR: DMBT1 is a gene that is highly unstable in cancer and encodes for a protein with at least two different functions, one in the immune defense and a second one in epithelial differentiation, according to expression analyses and studies with a monoclonal antibody against the protein.
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TL;DR: Results indicate that genetic alterations of TFF1 may lead to gastric mucosal barrier defects and contribute to the pathogenesis of gastric cancer.
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Hepatolithiasis in East Asia retrospective study
Fumio Nakayama,Roger D. Soloway,Terutsugu Nakama,Kohji Miyazaki,Hitoshi Ichimiya,Pai-Ching Sheen,C. G. Ker,G. B. Ong,T. K. Choi,J. Boey,W. C. Foong,E. C. Tan,K. H. Tung,C. N. Lee +13 more
TL;DR: The most significant finding was the difference in the relative prevalence of hepatolithiasis as a proportion of all gallstone cases in Taiwan, Hong Kong, and Singapore, where the majority of the population consisted of patients of Chinese descent.
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Are hepatolithiasis and cholangiocarcinoma aetiologically related? A morphological study of 12 cases of hepatolithiasis associated with cholangiocarcinoma.
TL;DR: It is speculated that chronic proliferative cholangitis in the presence of hepatolithiasis can undergo progressive changes to atypical epithelial hyperplasia which may in turn progress to Cholangiocarcinoma.
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Glandular elements around the intrahepatic bile ducts in man ; their morphology and distribution in normal livers
TL;DR: The morphology and distribution of the glandular elements around the intrahepatic bile ducts, hitherto poorly described, were examined in autopsied human livers with the aid of postmortem cholangiographs and revealed that neither gland communicated with the hepatic parenchyma, and the extramural glands drained into the large bileduct lumina via the conduits.
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