Open AccessJournal Article
Decrease of circulating dendritic cells in burn patients.
D'Arpa A,A. Accardo-Palumbo,G. Amato,L. D’Amelio,B. Napoli,D. Pileri,Cataldo,R. Mogavero,C. Lombardo,F. Conte +9 more
TL;DR: The data from the present study suggest that theDC percentage decreased early after burn injury, and in the presence of severe sepsis, the DC percentage remained lower until day 14, which may contribute to the immunosuppression observed after burn injuries.
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Abstract: Burn injury is associated with immune suppression and the subsequent development of sepsis. Severe burn injury is associated with depressed immune response, including a functional impairment of Th1 lymphocytes and natural killer cells and a decrease in interferon-a production. Dendritic cells (DCs) are potent antigen-presenting cells and play a key role in T cell activation; they are essential in coordinating the host response to pathogens. Using three-colour flow cytometry, we determined the percentage of lineage-negative LIN-DR+ DCs in burn patients and healthy subjects. The percentages of DCs were lower in the circulation of septic than in nonseptic patients and healthy subjects at all times examined (14 days) after burn injury. In contrast, the DC percentage in nonseptic patients was low at day 1, increased from day 3 to day 10, and reverted to normal levels at day 14. The data from the present study suggest that the DC percentage decreased early after burn injury. In addition, in the presence of severe sepsis, the DC percentage remained lower until day 14. This DC reduction may contribute to the immunosuppression observed after burn injury.
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Citations
Circulating dendritic cells following burn.
N. D’Arpa,A. Accardo-Palumbo,Giuseppe Amato,L. D’Amelio,D. Pileri,V. Cataldo,R. Mogavero,C. Lombardo,B. Napoli,F. Conte +9 more
TL;DR: Findings suggest that deficiencies in mDCs and pDC subsets are related to sepsis following severe burn, and may contribute to immunosuppression among burn victims.
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Reduction of plasma granzyme A correlates with severity of sepsis in burn patients.
A. Accardo-Palumbo,L. D’Amelio,D. Pileri,N. D’Arpa,R. Mogavero,G. Amato,V. Cataldo,B. Napoli,Francesco Ciccia,C. Lombardo,F. Conte +10 more
TL;DR: Because this is a retrospective study, Granzyme A is not a confirmed predictor of septic outcome after burn, but its determination could give useful information about the development and severity of sepsis.
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Serum immunoglobulin levels in pediatric burn patients
TL;DR: Although the drop in the serum concentration of immunoglobulins is irrespective to the burn size, more severe burn is associated with more decrease inThe serum levels of IgA, IgM, IgG and its subclasses, however, further studies are needed to provide complementary data on this issue.
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•Journal Article
Serum Levels of Cortisol, Immunoglobulin, and C-reactive Protein in Burn Patients
D. Pileri,A. Accardo-Palumbo,L. D’Amelio,N. D’Arpa,G. Arnone,C. Grisaffi,M. Amico,R. Brancato,C. Lombardo,F. Conte +9 more
TL;DR: The results suggest that increased cortisol and decreased immunoglobulin levels could be related to severe sepsis and clinical outcome.
Data Driven Analysis Reveals Shared Transcriptome Response, Immune Cell Composition, and Distinct Mortality Rates Across Differing Etiologies of Critical Illness.
TL;DR: Two consistent subgroups of critical illness are identified based on serum transcriptomics and derived immune cell fractions, with significantly different survival rates, which may serve as a universal predictor of complicated clinical course or treatment response and, importantly, may identify opportunities for subgroup-specific immunomodulatory intervention.
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TL;DR: The origins and migration of DCs to their sites of activity, their basic biology as antigen-presenting cells, their roles in important human diseases and, finally, selected strategies being pursued to harness their potent antigen-stimulating activity are addressed.
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Sepsis Induces Apoptosis and Profound Depletion of Splenic Interdigitating and Follicular Dendritic Cells
Kevin W. Tinsley,Mitchell H. Grayson,Paul E. Swanson,Anne M. Drewry,Katherine Chang,Irene E. Karl,Richard S. Hotchkiss +6 more
TL;DR: Sepsis induced profound apoptosis induced loss of FDCs and IDCs may significantly compromise B and T cell function and impair the ability of the host to survive sepsis.
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