Decrease in Plasma Cyclophilin A Concentration at 1 Month after Myocardial Infarction Predicts Better Left Ventricular Performance and Synchronicity at 6 Months: A Pilot Study in Patients with ST Elevation Myocardial Infarction
TL;DR: Investigation of the relationships between changes in plasma CyPA concentrations and LV remodeling in patients with ST-elevation myocardial infarction found decreased CyPA concentration at one-month follow-up after STEMI was associated with better LVEF and SDI at six months.
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Abstract: Background: Cyclophilin A (CyPA) concentration increases in acute coronary syndrome. In an animal model of acute myocardial infarction, administration of angiotensin-converting-enzyme inhibitor was associated with lower left ventricular (LV) CyPA concentration and improved LV performance. This study investigated the relationships between changes in plasma CyPA concentrations and LV remodeling in patients with ST-elevation myocardial infarction (STEMI).
Methods and Results: We enrolled 55 patients who underwent percutaneous coronary intervention for acute STEMI. Plasma CyPA, matrix metalloproteinase (MMP), interleukin-6 and high-sensitivity C-reactive protein concentrations were measured at baseline and at one-month follow-up. Echocardiography was performed at baseline and at one-, three-, and six-month follow-up. Patients with a decrease in baseline CyPA concentration at one-month follow-up (n = 28) had a significant increase in LV ejection fraction (LVEF) (from 60.2 ± 11.5% to 64.6 ± 9.9%, p < 0. 001) and preserved LV synchrony at six months. Patients without a decrease in CyPA concentration at one month (n = 27) did not show improvement in LVEF and had a significantly increased systolic dyssynchrony index (SDI) (from 1.170 ± 0.510% to 1.637 ± 1.299%, p = 0.042) at six months. Multiple linear regression analysis showed a significant association between one-month CyPA concentration and six-month LVEF. The one-month MMP-2 concentration was positively correlated with one-month CyPA concentration and LV SDI.
Conclusions: Decreased CyPA concentration at one-month follow-up after STEMI was associated with better LVEF and SDI at six months. Changes in CyPA, therefore, may be a prognosticator of patient outcome.
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Citations
Prognostic Impacts of Plasma Levels of Cyclophilin A in Patients With Coronary Artery Disease.
Tomohiro Ohtsuki,Kimio Satoh,Junichi Omura,Nobuhiro Kikuchi,Taijyu Satoh,Ryo Kurosawa,Masamichi Nogi,Shinichiro Sunamura,Nobuhiro Yaoita,Tatsuo Aoki,Shunsuke Tatebe,Koichiro Sugimura,Jun Takahashi,Satoshi Miyata,Hiroaki Shimokawa +14 more
TL;DR: The results indicate that plasma CyPA levels can be used to predict all-cause death, rehospitalization, and coronary revascularization in patients with coronary artery disease and that when combined with other biomarkers (hsCRP and brain natriuretic peptide levels), the CyPA Levels have further enhanced prognostic impacts in those patients.
45
A proteomic approach to assess the host response in gills of farmed Atlantic salmon Salmo salar L. affected by amoebic gill disease
M Marcos-López,Hamish D. Rodger,Ian O'Connor,M. Braceland,Richard Burchmore,P. David Eckersall,Eugene MacCarthy +6 more
TL;DR: This is the first sequential proteomic analysis of gills during N. perurans infection, and it is believed that the use of non-target screening techniques can contribute to the knowledge of gill responses to injury and pathogenic insults, including AGD.
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The roles of CyPA and CD147 in cardiac remodelling.
Hongyan Su,Yi Yang +1 more
TL;DR: The potential roles of CyPA and CD147 in cardiac remodelling and their implications for the development of novel pharmacological therapies for heart failure are reviewed.
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Serum cyclophilin A concentrations and prognosis of acute intracerebral hemorrhage.
Bin Chen,Jia Shen,Guan-Rong Zheng,Shen-Zhong Qiu,Huai-Ming Yin,Wei Mao,Hong-Xiang Wang,Jian-Bo Gao +7 more
TL;DR: Increasted serum cyclophilin A concentrations are highly associated with stroke severity and prognosis after hemorrhagic stroke and could significantly improve the prognostic predictive ability of NIHSS scores or hematoma volume alone.
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Analyses of the toxic properties of recombinant human Cyclophilin A in mice.
Anastasiya Kalinina,Mariya Zamkova,E E Antoshina,L S Trukhanova,Tatyana Gorkova,Dmitriy B. Kazansky,L. M. Khromykh +6 more
TL;DR: Investigation of the acute toxicity of a single intraperitoneal or subcutaneous dosing of recombinant human CypA in both female and male mice and its effect on gene expression of acute phase proteins in the female mice after IP treatment showed that toxicity of rhCypA was most evident in female andmale mice dosed IP with 750 mg/kg, and manifested as kidney injury and increased granulocyte/lymphocyte ratios in the blood.
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