Deciphering the molecular basis of memory failure in Alzheimer's disease.
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TL;DR: Experiments in rodents suggest that soluble oligomers of the amyloid beta protein (Abeta) may discretely interfere with synaptic mechanisms mediating aspects of learning and memory, including long-term potentiation.
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About: This article is published in Neuron. The article was published on 30 Sep 2004. and is currently open access. The article focuses on the topics: Memory impairment & Long-term potentiation.
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Citations
Anesthetics promoting in vitro AβPP metabolism and amyloid-β toxicity.
TL;DR: In this article, the effects of anesthetics on the metabolism of amyloid precursor protein and its metabolite amylβ were investigated in vitro studies, and the relevance of a possible interaction between anesthetic and AD is growing as well.
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Treating Alzheimer’s Disease with Brain Stimulation: From preclinical models to non-invasive stimulation in humans
Ilenia Lanni,Giulia Chiacchierini,Costanza Papagno,Valerio Santangelo,Patrizia Campolongo +4 more
TL;DR: Critically assessed recent findings in AD research belonging to animal studies and preclinical models and the effectiveness of interventions such as Optogenetics and Chemogenetics, shedding light on their implications for understanding pathophysiological mechanisms and potential therapeutic applications.
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SEN1500, a novel oral amyloid-β aggregation inhibitor, attenuates brain pathology in a mouse model of Alzheimer's disease.
TL;DR: SEN1500 is not only able to reduce Aβ pathology and activated microglia but also to improve learning and memory as previously shown, making SEN1500 a potential candidate for human AD treatment.
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•Dissertation
Vieillissement olfactif chez la souris normale et chez la souris APP/PS1, modèle de la maladie d'Alzheimer : implications de la neurogenèse et du système noradrénergique
Nolwen Rey
- 01 Dec 2010
TL;DR: In this paper, the effect of the depletion noradrenergique on the perception olfactives of the human brain was investigated, and the results showed that the effects of this depletion on the human perception of olfactive olfacts are correlated with the severity of the maladie d'Alzheimer.
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Preclinical models of alzheimer's disease for identification and preclinical validation of therapeutic targets: from fine-tuning strategies for validated targets to new venues for therapy
Bruno Barbosa de Vasconcelos,Matthew Bird,Ilie-Cosmin Stancu,Dick Terwel,Ilse Dewachter +4 more
- 01 Jan 2017
TL;DR: This work reviews the use of preclinical models for identification of targets for disease-modifying therapies, focusing on the initial validation of targets currently tested in clinical trials, their constraints and subsequent fine-tuning, and on new venues for future therapies currently under study in preclinical model.
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References
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
John Hardy,Dennis J. Selkoe +1 more
TL;DR: It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide in plaques in brain tissue and the rest of the disease process is proposed to result from an imbalance between Aβ production and Aβ clearance.
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
Elizabeth H. Corder,Ann M. Saunders,Warren J. Strittmatter,Donald E. Schmechel,P. C. Gaskell,Gary W. Small,A. D. Roses,Jonathan L. Haines,Margaret A. Pericak-Vance +8 more
TL;DR: The APOE-epsilon 4 allele is associated with the common late onset familial and sporadic forms of Alzheimer9s disease (AD) in 42 families with late onset AD.
9.6K
Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
George G. Glenner,Caine W. Wong +1 more
TL;DR: A purified protein derived from the twisted beta-pleated sheet fibrils in cerebrovascular amyloidosis associated with Alzheimer's disease has been isolated and Amino acid sequence analysis and a computer search reveals this protein to have no homology with any protein sequenced thus far.
5.2K
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
Jie Kang,H. G. Lemaire,A. Unterbeck,J. M. Salbaum,Colin L. Masters,K.-H. Grzeschik,Gerd Multhaup,Konrad Beyreuther,Benno Müller-Hill +8 more
TL;DR: An apparently full-length complementary DNA clone coding for the A4 polypeptide is isolated and sequenced and suggests that the cerebral amyloid deposited in Alzheimer's disease and aged Down's syndrome is caused by aberrant catabolism of a cell-surface receptor.
4.9K
Amyloid plaque core protein in Alzheimer disease and Down syndrome
Colin L. Masters,Gail Simms,Nicola A. Weinman,Gerd Multhaup,Brian L. McDonald,Konrad Beyreuther +5 more
TL;DR: The shared 4-kDa subunit indicates a common origin for the amyloids of the plaque core and of the congophilic angiopathy of Alzheimer disease and Down syndrome.
4.7K