Deciphering the Molecular and Functional Basis of RHOGAP Family Proteins A SYSTEMATIC APPROACH TOWARD SELECTIVE INACTIVATION OF RHO FAMILY PROTEINS
Ehsan Amin,Mamta Jaiswal,Urszula Derewenda,Katarina Reis,Kazem Nouri,Katja T. Koessmeier,Pontus Aspenström,Avril V. Somlyo,Radovan Dvorsky,Mohammad Reza Ahmadian +9 more
99
TL;DR: The sequence-structure-function relationship between RHOGAPs and RHO proteins is comprehensively investigated by combining in vitro data with in silico data and it is proposed that other domains of RHOG APs confer substrate specificity and fine-tune their catalytic efficiency in cells.
read more
About: This article is published in Journal of Biological Chemistry. The article was published on 23 Sep 2016. and is currently open access. The article focuses on the topics: RhoGAP domain & GTPase-activating protein.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
PerMemDB: A database for eukaryotic peripheral membrane proteins.
TL;DR: PerMemDB is currently the most complete and comprehensive repository of data for eukaryotic peripheral membrane proteins deposited in UniProt or predicted with the use of MBPpred - a computational method that specializes in the detection of proteins that interact non-covalently with membrane lipids, via membrane binding domains.
Rho GTPase regulatory proteins in podocytes
TL;DR: Recent advances in the understanding of the role of Rho GTPase regulatory proteins in podocytes are summarized, including the known mutations of these proteins that cause proteinuria in humans.
MicroRNA Regulation of the Small Rho GTPase Regulators-Complexities and Opportunities in Targeting Cancer Metastasis.
TL;DR: Recent exciting findings showing that miRNAs play important roles in regulating Rho GTPase regulators (RhoGEFs, RhoGAPs, RHoGDIs), thus affecting RhogTPase activities and cancer metastasis are summarized.
The N-Terminal GTPase Domain of p190RhoGAP Proteins Is a PseudoGTPase.
Amy L. Stiegler,Titus J. Boggon +1 more
TL;DR: It is found that GTP constitutively purifies with the N-GTPase domain, and a 2.8-Å crystal structure of p190RhoGAP-A co-purified with GTP reveals an unusual GTP-Mg2+ binding pocket, which supports that N- GTPase is a nucleotide binding, non-hydrolyzing, pseudoGTPases domain that may act as a protein-protein interaction domain.
Family with sequence similarity 13 member A mediates TGF-β1-induced EMT in small airway epithelium of patients with chronic obstructive pulmonary disease.
TL;DR: In this article, the role of FAM13A in TGF-β1-induced EMT in the small airway epithelium of patients with chronic obstructive pulmonary disease (COPD).
References
Coot: model-building tools for molecular graphics.
Paul Emsley,Kevin Cowtan +1 more
TL;DR: CCP4mg is a project that aims to provide a general-purpose tool for structural biologists, providing tools for X-ray structure solution, structure comparison and analysis, and publication-quality graphics.
Biopython: freely available Python tools for computational molecular biology and bioinformatics
Peter J. A. Cock,Tiago Antao,Jeffrey T. Chang,Brad Chapman,Cymon J. Cox,Andrew Dalke,Iddo Friedberg,Thomas Hamelryck,Frank Kauff,Bartosz Wilczyński,Michiel J. L. de Hoon +10 more
TL;DR: Biopython includes modules for reading and writing different sequence file formats and multiple sequence alignments, dealing with 3D macro molecular structures, interacting with common tools such as BLAST, ClustalW and EMBOSS, accessing key online databases, as well as providing numerical methods for statistical learning.
Towards automated crystallographic structure refinement with phenix.refine
Pavel V. Afonine,Ralf W. Grosse-Kunstleve,Nathaniel Echols,Jeffrey J. Headd,Nigel W. Moriarty,Marat Mustyakimov,Thomas C. Terwilliger,Alexandre Urzhumtsev,Alexandre Urzhumtsev,Peter H. Zwart,Paul D. Adams,Paul D. Adams +11 more
TL;DR: This paper presents an overview of the major phenix.refine features, with extensive literature references for readers interested in more detailed discussions of the methods.