Deciphering the Molecular and Functional Basis of RHOGAP Family Proteins A SYSTEMATIC APPROACH TOWARD SELECTIVE INACTIVATION OF RHO FAMILY PROTEINS

TL;DR: A deep learning-based phase retrieval method is proposed for X-ray single-particle imaging, achieving low-resolution estimates in a fraction of the time required by traditional methods, and can be used as support for further analysis of biological macromolecules.

TL;DR: This study uses proximity-dependent biotin identification (BioID) to map the interactomes of RhoA, Rac1, and Cdc42 in human podocytes, identifying 1927 interactions, including novel regulators and effectors, and shedding light on the Rho GTPase signaling networks in kidney podocytes.

TL;DR: It is demonstrated that ROP signaling was established early in the streptophyte lineage, sometime after the divergence of the Chlorokybophyceae/Mesostigmatophycee lineage, but before the divergenceOf the Klebsormidiophyeae lineage, which corresponds to when the unicellular-to-multicellular transition likely took place in the Streptophytes.

TL;DR: CCP4mg is a project that aims to provide a general-purpose tool for structural biologists, providing tools for X-ray structure solution, structure comparison and analysis, and publication-quality graphics.

TL;DR: Biopython includes modules for reading and writing different sequence file formats and multiple sequence alignments, dealing with 3D macro molecular structures, interacting with common tools such as BLAST, ClustalW and EMBOSS, accessing key online databases, as well as providing numerical methods for statistical learning.

TL;DR: This paper presents an overview of the major phenix.refine features, with extensive literature references for readers interested in more detailed discussions of the methods.