Decellularization method for scaffoldless tissue engineered articular cartilage or native cartilage tissue

TL;DR: In this article, an implantable composition can include methacrylated solubilized devitalized cartilage (MeSDVC) with or without DVC (devitalized Cartilage) particles.

TL;DR: An implantable hydrogel precursor composition can include: a cross-linkable polymer matrix that is biocompatible; and a plurality of polymer particles in the crosslinkable matrix as discussed by the authors.

TL;DR: In this paper, the authors provide compositions and methods for engineering cartilage of clinically-relevant geometry and biomechanical properties in particular, the present disclosure provides processes involving expansion, redifferentiation and construct formation to provide neocartilage, which resembles native cartilage.

TL;DR: To choose the most relevant source and processing for cartilage matrix, qualifying testing needs to include targeting the desired application, optimizing delivery of the material, identify relevant FDA regulations, assess availability of raw materials, and immunogenic properties of the product.

TL;DR: In this paper, a decellularized bone marrow extracellular matrix and uses thereof for repairing or regenerating defective, diseased, damaged or ischemic tissues or organs in a subject, preferably a human, is presented.

TL;DR: In this article, a method for simultaneous application of an ionic detergent and a non-ionic detergent for a long time period, which may exceed five days, is described.

TL;DR: In this article, the authors provide a method for forming tissue-engineered constructs without the use of scaffolds and associated methods of use in tissue replacement using a shape hydrogel negative mold.

TL;DR: In this article, a negative mold having a defined shape is used to construct a living tissue construct, which can then be surgically implanted into a patient for a suitable incubation period.