Cytotoxic T-lymphocyte antigen 4 polymorphisms and breast cancer susceptibility: Evidence from a meta-analysis
Ming-Cheng Lee,Kate Bridgman +1 more
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TL;DR: Wang et al. as mentioned in this paper performed a meta-analysis to investigate the potential effects of five polymorphisms (-1722 T/C, -1661 A/G -318 C/T, +49 A/Gs, and CT60 A/g) on breast cancer susceptibility.
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Abstract: Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is an immune checkpoint and regulates the immune function of T cells. However, previous findings regarding the association of CTLA-4 polymorphisms and breast cancer remain inconclusive. Therefore, we performed a meta-analysis to investigate the potential effects of five polymorphisms (-1722 T/C, -1661 A/G -318 C/T, +49 A/G, and CT60 A/G) in the CTLA-4 gene on breast cancer susceptibility.Relevant literatures were systematically searched through electronic databases including PubMed, EMBASE, and Web of Science up to October 10, 2021. Available data were extracted and odds ratios (ORs) with 95% confidence intervals were used to estimate the pooling effect size. The Newcastle-Ottawa Scale was applied for assessing the quality of included studies. We conducted subgroup analyses based on ethnicity and control sources to explore levels of heterogeneity. Moreover, sensitivity analysis and publication bias were assessed.Finally, a total of 12 eligible studies regarding CTLA-4 polymorphisms and breast cancer were included. For overall analyses, only the +49 A/G polymorphism was significantly associated with breast cancer under allelic (OR = 1.19), dominant (OR = 1.27), and recessive (OR = 1.27) models. Ethnicity-based subgroup analysis found that the +49 A/G polymorphism has a significant risk (OR = 2.03) of breast cancer under the recessive model in the non-Asian population. Studies with hospital-based controls showed that the +49 A/G polymorphism has significant breast cancer risks under allelic (OR = 1.44), dominant (OR = 1.86), and recessive (OR = 1.60) models. In addition, those with population-based controls found that -1722 T/C polymorphism has a significant breast cancer risk under allelic (OR = 1.19) and dominant (OR = 1.26) models.This meta-analysis suggested that CTLA-4 + 49 A/G polymorphism may significantly associate with breast cancer susceptibility. Future studies containing various populations are helpful for evaluating the impacts of CTLA-4 polymorphisms on breast cancer susceptibility.
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References
Complete sequence determination of the mouse and human CTLA4 gene loci: cross-species DNA sequence similarity beyond exon borders.
TL;DR: Sequence comparison between the mouse and the human CTLA4 gene loci revealed a high degree of sequence conservation both for homologous noncoding regions and for coding regions, raising the possibility that constrained gene evolution of CTla4 may be linked to conserved transcriptional control of this locus.
86
Cytotoxic T lymphocyte antigen-4 gene in breast cancer.
Abbas Ghaderi,Farshid Yeganeh,Tahereh Kalantari,Abdul Rasoul Talei,Abdul Mohammad Pezeshki,Mehrnoosh Doroudchi,Alamtaj Samsami Dehaghani +6 more
TL;DR: The results indicated a significant difference between frequency of ctla-4 genotypes in patients and controls, and the observed decrease in the frequency of GG genotype in the breast cancer patients is contrary to the frequently reported increase of GG Genotype in autoimmune diseases.
84
•Journal Article
CTLA4 gene variants in autoimmunity and cancer: a comparative review.
TL;DR: The hypothesis that individuals inheriting a GG genotype at position +49, for which lower CTLA4 expression has been extensively suggested, are more susceptible for developing autoimmune disorders and those with AA genotype, with an existence of a state of self-tolerance, may have a higher chance of developing cancer is supported.
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Association of CTLA-4 gene polymorphisms with sporadic breast cancer risk and clinical features in Han women of Northeast China
TL;DR: The results indicate that some SNPs in the CTLA-4 gene may affect the risk of breast cancer and show that someSNPs are associated with breast cancer characteristics in Han women in northeastern China.
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Functional genetic variants of CTLA-4 and risk of tobacco-related oral carcinoma in high-risk North Indian population
TL;DR: Significant risk modifying effects of CTLA-4 -1722C/T, -1661A/G, -318T/C, CT60 A/G and 49A-G SNPs in tobacco-related OSCC in North Indian population are suggested.
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