Cytokines, inflammation, and pain.
Jun-Ming Zhang,Jianxiong An +1 more
TL;DR: There is significant evidence showing that certain cytokines/chemokines are involved in not only the initiation but also the persistence of pathologic pain by directly activating nociceptive sensory neurons.
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Abstract: Cytokines are small secreted proteins released by cells have a specific effect on the interactions and communications between cells. Cytokine is a general name; other names include lymphokine (cytokines made by lymphocytes), monokine (cytokines made by monocytes), chemokine (cytokines with chemotactic activities), and interleukin (cytokines made by one leukocyte and acting on other leukocytes). Cytokines may act on the cells that secrete them (autocrine action), on nearby cells (paracrine action), or in some instances on distant cells (endocrine action). There are both pro-inflammatory cytokines and anti-inflammatory cytokines. There is significant evidence showing that certain cytokines/chemokines are involved in not only the initiation but also the persistence of pathologic pain by directly activating nociceptive sensory neurons. Certain inflammatory cytokines are also involved in nerve-injury/inflammation-induced central sensitization, and are related to the development of contralateral hyperalgesia/allodynia. The discussion presented in this chapter describes several key pro-inflammatory cytokines/chemokines and anti-inflammatory cytokines, their relation with pathological pain in animals and human patients, and possible underlying mechanisms.
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References
Blockade of Microglial Activation Is Neuroprotective in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson Disease
Du Chu Wu,Vernice Jackson-Lewis,Miquel Vila,Kim Tieu,Peter Teismann,Caryn Vadseth,Dong-Kug Choi,Harry Ischiropoulos,Serge Przedborski +8 more
TL;DR: It is shown that minocycline, an approved tetracycline derivative that inhibits microglial activation independently of its antimicrobial properties, mitigates both the demise of nigrostriatal dopaminergic neurons and the formation of nitrotyrosine produced by MPTP.
1.2K
Nitric oxide (NO) and nociceptive processing in the spinal cord.
Stephen T. Meller,G.F. Gebhart +1 more
TL;DR: These reports suggest that the reflex withdrawal response to noxious heat is not mediated through activation of NMDA receptors and subsequent production of NO and cGMP, but that the acute NMDA-produced facilitation of thermal reflexes is NMDA-, NO- andcGMP-mediated.
1K
The pivotal role of tumour necrosis factor α in the development of inflammatory hyperalgesia
TL;DR: Results show that TNFα has an early and crucial role in the development of inflammatory hyperaglesia and the finding that the production of these cytokines is inhibited by steroidal anti‐inflammatory drugs provides a mechanism of action for these drugs in the treatment ofinflammatory hyperalgesia.
802
Physiological actions and clinical applications of transforming growth factor-beta (TGF-beta).
TL;DR: In vivo roles of TGF-β will be considered in the context of the inherent complexity of cell-matrix and cell-cell interactions characteristic of mixed cell populations, tissues, or organs.
780
Beyond Neurons: Evidence That Immune and Glial Cells Contribute to Pathological Pain States
Linda R. Watkins,Steven F. Maier +1 more
TL;DR: All nerves and neurons regardless of modality or function are likely affected by immune and glial activation in the ways described for pain, and proinflammatory cytokines appear to be of special importance in the creation of peripheral nerve and neuronal hyperexcitability.
770