Journal Article10.1016/S1286-4579(01)01479-4
Cytokines in host defense against Salmonella.
Lars Eckmann,Martin F. Kagnoff +1 more
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TL;DR: Infection with Salmonella induces expression of multiple chemokines and proinflammatory cytokines in cultured intestinal epithelial cells and macrophages, and protective roles have been shown for IL-1alpha, TNFalpha, IFN-gamma, IL-12,IL-18 and IL-15, whereas IL-4 andIL-10 inhibit host defenses against Salmoneella.
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About: This article is published in Microbes and Infection. The article was published on 01 Nov 2001. The article focuses on the topics: Proinflammatory cytokine & Innate immune system.
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Citations
Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells.
Monica Rimoldi,Marcello Chieppa,Marcello Chieppa,Valentina Salucci,Francesca Avogadri,Angelica Sonzogni,Gianluca M. Sampietro,Angelo Nespoli,Giuseppe Viale,Giuseppe Viale,Paola Allavena,Maria Rescigno +11 more
TL;DR: The intimate interplay between intestinal epithelial cells and dendritic cells may help to maintain gut immune homeostasis.
867
Salmonella, the host and disease: a brief review
TL;DR: This review explores some of the host and pathogenic mechanisms mobilized in the two predominant clinical syndromes associated with infection with Salmonella enterica species: enterocolitis and typhoid.
Organotypic 3D cell culture models: using the rotating wall vessel to study host–pathogen interactions
Jennifer Barrila,Andrea L. Radtke,Aurélie Crabbé,Shameema Sarker,Melissa M. Herbst-Kralovetz,Melissa M. Herbst-Kralovetz,C. Mark Ott,Cheryl A. Nickerson +7 more
TL;DR: This Review highlights how the rotating wall vessel bioreactor has been used to establish 3D hierarchical models that range in complexity from a single cell type to multicellular co-culture models that recapitulate the 3D architecture of tissues observed in vivo.
312
TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system.
Edward A. Miao,Erica Andersen-Nissen,Erica Andersen-Nissen,Sarah E. Warren,Sarah E. Warren,Alan Aderem +5 more
TL;DR: In macrophages infected with Salmonella typhimurium or Legionella pneumophila, Ipaf becomes activated in response to flagellin that appears to be delivered to the cytosol via specific virulence factor transport systems.
311
Role of innate immunity in Helicobacter pylori-induced gastric malignancy.
TL;DR: Identification of bacterial and host mediators that augment disease risk has profound ramifications for both biomedical researchers and clinicians as such findings will provide mechanistic insights into inflammatory carcinogenesis and serve to identify high-risk populations of H. pylori-infected individuals who can then be targeted for therapeutic intervention.
References
A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion.
Hyun Chae Jung,Lars Eckmann,Suk-Kyun Yang,Asit Panja,Joshua Fierer,E. Morzycka-Wroblewska,Martin F. Kagnoff +6 more
TL;DR: Since the cytokines expressed in response to bacterial invasion or other proinflammatory agonists have a well documented role in chemotaxis and activation of inflammatory cells, colon epithelial cells appear to be programmed to provide a set of signals for the activation of the mucosal inflammatory response in the earliest phases after microbial invasion.
Severe Mycobacterial and Salmonella Infections in Interleukin-12 Receptor-Deficient Patients
Rolien de Jong,Frédéric Altare,Inez-Anne Haagen,Diënne G. Elferink,Tjitske de Boer,Peter J. C. van Breda Vriesman,Peter J. Kabel,Johannes M. T. Draaisma,Jaap T. van Dissel,Frank P. Kroon,Jean-Laurent Casanova,Tom H. M. Ottenhoff +11 more
TL;DR: The lack of IL-12Rbeta1 expression results in a human immunodeficiency and shows the essential role in resistance to infections due to intracellular bacteria.
871
Salmonella typhimurium attachment to human intestinal epithelial monolayers: transcellular signalling to subepithelial neutrophils.
TL;DR: A novel transcellular pathway exists in which subepithelial PMN respond to lumenal pathogens across a functionally intact epithelium, and it is speculated that IL-8 may act in concert with an as yet unidentified trans cellular chemotactic factor(s) (TCF) which directs PMN migration across the intestinal epithelia.
Inherited interleukin 12 deficiency in a child with bacille Calmette-Guérin and Salmonella enteritidis disseminated infection.
Frédéric Altare,David A. Lammas,Patrick Revy,Emmanuelle Jouanguy,Rainer Doffinger,S Lamhamedi,Pamela Drysdale,Dagmar Scheel-Toellner,John Girdlestone,P. Darbyshire,M Wadhwa,Hazel M. Dockrell,Mike Salmon,A Fischer,Anne Durandy,Jean-Laurent Casanova,D S Kumararatne +16 more
TL;DR: The discovery of the first discovered human disease resulting from a cytokine gene defect suggests that IL-12 is essential to and appears specific for protective immunity to intracellular bacteria such as mycobacteria and salmonella.
Interleukin 18 Contributes to Host Resistance and Gamma Interferon Production in Mice Infected with Virulent Salmonella typhimurium
Pietro Mastroeni,Simon Clare,Shahid A. Khan,J. A. Harrison,C E Hormaeche,Haruki Okamura,M. Kurimoto,G. Dougan +7 more
TL;DR: IL-18 proved to be required for IFN-γ production by mouse splenocytes from conventional, scid, andrag-1−/− mice; in vivo IL-18 neutralization caused a decrease in circulating IFn-γ levels, indicating that IL- 18 is a key factor in early host resistance to Salmonella and probably acts via IFN -γ.
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