Journal Article10.1016/J.JURO.2008.04.001
Cytokines in Epithelial-Mesenchymal Transition: A New Insight Into Obstructive Nephropathy
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TL;DR: Etithelial-mesenchymal transition is an orchestrated, highly regulated process that proceeds in stepwise fashion and appears to contribute significantly to renal fibrosis and the progression of chronic renal disease.
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About: This article is published in The Journal of Urology. The article was published on 01 Aug 2008. The article focuses on the topics: Renal fibrosis & End stage renal disease.
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Citations
A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy
Maoyin Pang,Li Ma,Rujun Gong,Evelyn Tolbert,Haiping Mao,Murugavel Ponnusamy,Y. Eugene Chin,Haidong Yan,Lance D. Dworkin,Shougang Zhuang +9 more
TL;DR: Increased STAT3 activity mediates activation of renal interstitial fibroblasts and the progression of renal fibrosis, and inhibition of STAT3 signaling with S3I-201 may hold therapeutic potential for fibrotic kidney diseases.
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Pirfenidone suppresses MAPK signalling pathway to reverse epithelial-mesenchymal transition and renal fibrosis.
TL;DR: The potential effects of PFD on epithelial‐to‐mesenchymal transition (EMT) and renal fibrosis in a unilateral ureteral obstruction rat model and the involved molecular mechanism related to cultured human renal proximal tubular epithelial cells (HK‐2) are investigated.
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Therapeutic applications of mesenchymal stem cells to repair kidney injury.
TL;DR: Experimental evidence suggests that administering exogenous mesenchymal stem cells during acute and chronic kidney injury may improve functional and structural recovery of the tubular, glomerular and interstitial kidney compartments.
90
Nephrocalcinosis: new insights into mechanisms and consequences
TL;DR: Current understanding of the mechanisms involved in both types of nephrocalcinosis (intratubular and interstitial), their possible consequences and their relation to calcium nephrolithiasis are discussed.
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Arterially Delivered Mesenchymal Stem Cells Prevent Obstruction-Induced Renal Fibrosis
Hiroshi Asanuma,Brian A. VanderBrink,Matthew T. Campbell,Karen L. Hile,Hongji Zhang,Daniel R. Meldrum,Kirstan K. Meldrum +6 more
TL;DR: Human bone marrow-derived MSCs remain viable several weeks after delivery into the kidney and provide protection against obstruction-induced EMT and chronic renal fibrosis, demonstrating that alterations in TNF-α production may be involved.
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References
Renoprotective Effect of the Angiotensin-Receptor Antagonist Irbesartan in Patients with Nephropathy Due to Type 2 Diabetes
Edmond J Lewis,Lawrence G. Hunsicker,William R. Clarke,Tomas Berl,Marc A. Pohl,Julia B. Lewis,Eberhard Ritz,Robert C. Atkins,Richard D. Rohde,Itamar Raz +9 more
TL;DR: The angiotensin-II-receptor blocker irbesartan is effective in protecting against the progression of nephropathy due to type 2 diabetes, independent of the reduction in blood pressure it causes.
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The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression
Amparo Cano,Mirna Perez-Moreno,Isabel Rodrigo,Annamaria Locascio,Maria Blanco,Marta G. del Barrio,Francisco Portillo,M. Angela Nieto +7 more
TL;DR: It is shown that mouse Snail is a strong repressor of transcription of the E-cadherin gene, opening up new avenues for the design of specific anti-invasive drugs.
3.8K
Cloning of a new cytokine that induces IFN-gamma production by T cells.
Haruki Okamura,H Tsutsi,T Komatsu,M Yutsudo,A Hakura,T Tanimoto,K Torigoe,T Okura,Y Nukada,K Hattori +9 more
TL;DR: The cloning of a recently identified IFN-γ-inducing factor (IGIF) that augments natural killer activity in spleen cells and may be involved in the development of Thl cells and also in mechanisms of tissue injury in inflammatory reactions is reported.
2.6K
Evidence that fibroblasts derive from epithelium during tissue fibrosis
Masayuki Iwano,David Plieth,Theodore M. Danoff,Theodore M. Danoff,Chengsen Xue,Hirokazu Okada,Hirokazu Okada,Eric G. Neilson +7 more
TL;DR: The findings suggest that a substantial number of organ fibroblasts appear through a novel reversal in the direction of epithelial cell fate, which highlights the potential plasticity of differentiated cells in adult tissues under pathologic conditions.
BMP-7 counteracts TGF-β1–induced epithelial-to-mesenchymal transition and reverses chronic renal injury
Michael Zeisberg,Jun-ichi Hanai,Hikaru Sugimoto,Tadanori Mammoto,David M. Charytan,Frank Strutz,Raghu Kalluri +6 more
TL;DR: It is reported that BMP-7 reverses TGF-β1–induced epithelial-to-mesenchymal transition (EMT) by reinduction of E-cadherin, a key epithelial cell adhesion molecule, which provides evidence of cross talk between B MP-7 and TGF -β1 in the regulation of EMT in health and disease.
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