Open AccessJournal Article
Cyclosporine-induced deterioration in patients with AIDS
Anne Phillips,Mark A. Wainberg,R Coates,Marina B. Klein,Anita Rachlis,Stanley E. Read,F A Shepherd,Hillar Vellend,Sharon Walmsley,P Halloran +9 more
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TL;DR: The results of this pilot study indicate that cyclosporine does not alleviate, and may worsen, the symptoms and laboratory findings in patients with AIDS.
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Abstract: Eight patients with AIDS (acquired immune deficiency syndrome) but free of life-threatening infection were treated with the immunosuppressive drug cyclosporine for a mean of 53.9 days. The serum cyclosporine levels were maintained in the desired therapeutic range. All eight patients experienced severe toxic symptoms, which necessitated discontinuation of cyclosporine therapy in six. The serum levels of creatinine, urea and potassium rose during treatment and fell after therapy was stopped. The total leukocyte count, hemoglobin level, platelet count, total T-cell count, and T4- and T8-cell counts all fell markedly during treatment. The total leukocyte count, platelet count, and T4- and T8-cell counts rose after therapy was stopped, but the hemoglobin level remained low. No patient experienced resolution of symptoms during therapy, and the condition of all patients improved after treatment was stopped. The results of this pilot study indicate that cyclosporine does not alleviate, and may worsen, the symptoms and laboratory findings in patients with AIDS.
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The Effects of Cyclosporin A on the Immune System
TL;DR: The cyclosporins were originally discovered in 1970 by workers at Sandoz Ltd. in Switzerland who were attempting to identify new antifungal agents but appeared to be selective in its immunosuppressive effects because it had no effect on the survival of mice that had been inoculated with the L1210 leukemia line.
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Action and Toxicity of Cyclosporine
TL;DR: The unique action of the drug on T-cell immunity without myelosuppression is summarized and its pharmacology and adverse reactions, particularly nephrotoxicity, are reviewed.
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