Journal Article10.1016/J.CANLET.2004.06.014
Cyclooxygenases in cancer: progress and perspective.
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TL;DR: The rapid development of safe and effective inhibitors targeting individual COX enzymes not only dramatically improved the understanding of the function of COX-2, but also resulted in discovery ofCOX independent functions of NSAIDs, providing important hints for future drug design.
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About: This article is published in Cancer Letters. The article was published on 08 Nov 2004. The article focuses on the topics: Mouse model of colorectal and intestinal cancer & Cancer.
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Citations
Understanding the role of molecular and genetic alterations in proliferation and progression of oral squamous cell carcinoma : A review article
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TL;DR: Understanding the molecular and genetic alterations in proliferation and progression of oral squamous cell carcinoma involves exploring the genetic events that transform normal cells into cancerous ones, including alterations in tumor suppressor genes and oncogenes, growth factor production, and increased cell surface receptors and intracellular signal messengers.
Chronic inflammation and oxidative stress in the genesis and perpetuation of cancer: role of lipid peroxidation, DNA damage, and repair
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TL;DR: Persistent oxidative/nitrosative stress and excess LPO are induced by inflammatory processes in a self-perpetuating process and cause progressive accumulation of DNA damage in target organs, providing promising molecular signatures for risk prediction and potential targets and biomarkers for preventive measures.
Activation of the human FP prostanoid receptor disrupts mitosis progression and generates aneuploidy and polyploidy.
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TL;DR: Cell cycle analyses on HEK cells stably expressing the human FP receptor found that treatment with PGF2α delays mitosis and is associated with an increased expression of cyclin B1 and Cdc2 kinase activity, which suggests that FP receptor activation of Rho signaling by P GF2α can interfere with nuclear division.
Tumor Microenvironment in Head and Neck Squamous Cell Carcinoma
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TL;DR: Increased understanding of the TME in HNSCC illustrates that the long-held notion of "condemned mucosa" reflects a process that extends beyond the epithelial cells to the entire tissue comprised of each of these elements.
Inflammation-induced myeloid-derived suppressor cells associated with squamous cell carcinoma of the head and neck.
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TL;DR: The purpose of this study was to present the assessment of the significance of myeloid‐derived suppressor cells (MDSCs) in head and neck squamous cell carcinoma (HNSCC).
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