Journal Article10.1016/J.CANLET.2004.06.014
Cyclooxygenases in cancer: progress and perspective.
407
TL;DR: The rapid development of safe and effective inhibitors targeting individual COX enzymes not only dramatically improved the understanding of the function of COX-2, but also resulted in discovery ofCOX independent functions of NSAIDs, providing important hints for future drug design.
read more
About: This article is published in Cancer Letters. The article was published on 08 Nov 2004. The article focuses on the topics: Mouse model of colorectal and intestinal cancer & Cancer.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Mechanisms of Carcinogenesis in Prostate Cancer
Jose J. Correa,Julio M. Pow-Sang +1 more
- 01 Jan 2010
TL;DR: Genetic, hormonal and inflammatory factors that may contribute to the development of prostate cancer are reviewed.
6
The in vitro biological activities of three Hypoxis species and their active compounds
Gerhardt Johannes Boukes
- 01 Jan 2010
TL;DR: In this paper, the authors provided scientific data on the anticancer, anti-inflammatory and antioxidant properties of H. sobolifera chloroform extracts and their active compounds.
6
Cancer, cachexia, prostanoids, and NSAIDs.
TL;DR: Clinical studies of the effects of NSAIDs in cancer cachexia support the notion that NSAIDs can have benefi cial effects in cachectic cancer patients, according to the heterogeneity of the studies.
6
Cox-2 promotes chromogranin A expression and bioactivity: evidence for a prostaglandin E2-dependent mechanism and the involvement of a proximal cyclic adenosine 5'-monophosphate-responsive element.
R. Connolly,Damien Gates,Nellie Loh,Dilair Baban,Rajesh Thakker,Brian T. Johnston,David R. McCance,Joy Ardill,Daniel T. O'Connor,Laurent Taupenot,Ann McGinty +10 more
TL;DR: This study is the first to demonstrate that Cox-2 up-regulates both CGA expression and bioactivity in a neuro endocrine cell line and has major implications for the role of this polypeptide in the pathogenesis of neuroendocrine cancers in which Cox- 2 is up-regulated.
6
References
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
TL;DR: Experiments with guinea-pig lung suggest that some of the therapeutic effects of sodium salicylate and aspirin-like drugs are due to inhibition of the synthesis of prostaglandins.
8.8K
Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology
TL;DR: Important insights into the mechanisms of inflammatory responses, pain, and fever have been gleaned from the current understanding of eicosanoid biology.
3.8K
Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation
TL;DR: Leukotrienes C4, D4, and E4, which are released from the lung tissue of asthmatic subjects exposed to specific allergens, seem to play a pathophysiological role in immediate hypersensitivity reactions.
2.8K
Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas
Charles E. Eberhart,Robert J. Coffey,Aramandla Radhika,Francis M. Giardiello,Suzanne Ferrenbach,Raymond N. DuBois +5 more
TL;DR: COX-2, but not COX-1, gene expression is markedly elevated in most human colorectal cancers compared with accompanying normal mucosa, and COx-2 expression seems to be increased in a subset of adenomas.
2.6K
The Effect of Celecoxib, a Cyclooxygenase-2 Inhibitor, in Familial Adenomatous Polyposis
Gideon Steinbach,Patrick M. Lynch,R. K. S. Phillips,Marina Wallace,Ernest T. Hawk,Gary Gordon,Naoki Wakabayashi,Brian D. Saunders,Yu Shen,Takashi Fujimura,Li Kuo Su,Bernard Levin,Louis Godio,Sherri Patterson,Miguel A. Rodriguez-Bigas,Susan L. Jester,Karen L. King,Marta Schumacher,James L. Abbruzzese,Raymond N. DuBois,Walter N. Hittelman,Stuart O. Zimmerman,Jeffrey W. Sherman,Gary J. Kelloff +23 more
TL;DR: In patients with familial adenomatous polyposis, six months of twice-daily treatment with 400 mg of celecoxib, a cyclooxygenase-2 inhibitor, leads to a significant reduction in the number of colorectal polyps.
2.6K