Cyclins and cyclin-dependent kinases: Comparative study of hepatocellular carcinoma versus cirrhosis
Tsutomu Masaki,Yasushi Shiratori,William Rengifo,Kouichi Igarashi,Michiko Yamagata,Kazutaka Kurokohchi,Naohito Uchida,Yoshiaki Miyauchi,Hitoshi Yoshiji,Seishiro Watanabe,Masao Omata,Shigeki Kuriyama +11 more
TL;DR: The increases of cyclin D1, Cdk4, cyclin E, Cyclin A, and Wee1 play an important role in the development of HCC from cirrhosis and may be closely related to the histopathologic grade and progression of H CC.
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About: This article is published in Hepatology. The article was published on 01 Mar 2003. and is currently open access. The article focuses on the topics: Cyclin E & Cyclin D.
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Citations
•Journal Article
Notch1 signaling inhibits growth of human hepatocellular carcinoma through induction of cell cycle arrest and apoptosis.
Runzi Qi,Huazhang An,Yizhi Yu,Minghui Zhang,Shuxun Liu,Hongmei Xu,Zhenghong Guo,Tao Cheng,Xuetao Cao +8 more
TL;DR: It is shown that overexpression of Notch1 was able to inhibit the growth of HCC cells in vitro and in vivo, and suggest that Notch 1 signaling may participate in the development of H CC cells, affecting multiple pathways that control both cell proliferation and apoptosis.
Wee1 kinase as a target for cancer therapy
TL;DR: A review of the role of wee1 in the cell cycle and DNA replication is presented and the clinical development to date of this novel class of anticancer agents is summarized.
255
WEE1 Kinase Targeting Combined with DNA-Damaging Cancer Therapy Catalyzes Mitotic Catastrophe
Philip C. De Witt Hamer,Shahryar E. Mir,David P. Noske,Cornelis J.F. Van Noorden,Thomas Wurdinger +4 more
TL;DR: The combination of DNA-damaging cancer therapy with WEE1 inhibition seems to be a rational approach to push cancer cells in mitotic catastrophe.
Molecular targets and oxidative stress biomarkers in hepatocellular carcinoma: an overview
Monica Marra,I. Sordelli,Angela Lombardi,Monica Lamberti,Luciano Tarantino,Aldo Giudice,Paola Stiuso,Alberto Abbruzzese,Rossella Sperlongano,Marina Accardo,Massimo Agresti,Michele Caraglia,Pasquale Sperlongano +12 more
TL;DR: The detection of molecular factors predictive of response to anti-cancer agents such as sorafenib and the identification of mechanisms of resistance toAnti- cancer agents may probably represent the direction to improve the treatment of HCC.
New therapeutic strategies to treat human cancers expressing mutant p53 proteins.
TL;DR: Mouse models show that the genetic reconstitution of the wild type p53 tumor suppression functions rescues tumor growth, which strongly supports the notion that either restoring wt-p53 activity or inhibiting mutant p53 oncogenic activity could provide an efficient strategy to treat human cancers.
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