Journal Article10.1080/14656566.2019.1583745
Current pharmacotherapy for testicular germ cell cancer
22
TL;DR: The authors review the current standards of adjuvant chemotherapy for stage I GCTs as well as first-line and salvage treatments for metastatic disease and novel approaches for refractory disease.
read more
Abstract: Introduction: With the implementation of platinum-based chemotherapy, germ cell tumors (GCTs) became a model for a curable solid tumor, with survival rates of 95% in all patients with >80% survival...
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Copper Complexes as Anticancer Agents Targeting Topoisomerases I and II.
TL;DR: New emerging treatment aspects are depicted to encourage the expansion of this family of highly active anticancer drugs and to expend their use in clinical trials and future cancer therapy.
140
Lignans and Their Derivatives from Plants as Antivirals
TL;DR: Two types of antiviral lignan—podophyllotoxin and bicyclol, which are used to treat venereal warts and chronic hepatitis B in clinical, serve as examples of using lignans for antivirals—are discussed in some detail.
138
Podophyllotoxin and its derivatives: Potential anticancer agents of natural origin in cancer chemotherapy.
S. Motyka,Karolina Jafernik,Halina Ekiert,Javad Sharifi-Rad,Daniela Calina,Basem Al-Omari,Agnieszka Szopa,William C. Cho +7 more
TL;DR: In this paper , the authors discuss the therapeutic properties of PTOX as an important anticancer compound of natural origin, and the relevant information regarding the antitumor mechanisms of podophyllotoxin and its derivatives were collected and analyzed from scientific databases.
68
Natural Polyphenols as Modulators of Etoposide Anti-Cancer Activity
TL;DR: In this paper, the effects of polyphenols on the anti-cancer activity of etoposide in in vitro and in vivo studies were presented, which is a semi-synthetic derivative of podophyllotoxin.
38
Practice Makes Perfect: The Rest of the Story in Testicular Cancer as a Model Curable Neoplasm
Torgrim Tandstad,Christian Kollmannsberger,Bruce J. Roth,Claudio Jeldres,Silke Gillessen,Karim Fizazi,Siamak Daneshmand,William T. Lowrance,Nasser H. Hanna,Costantine Albany,Richard S. Foster,Gabriella Cohn Cedermark,Darren R. Feldman,Thomas Powles,Mark A. Lewis,Peter Grimison,Douglas Bank,Christopher C. Porter,Peter Albers,Maria De Santis,Sandy Srinivas,George J. Bosl,Craig R. Nichols +22 more
- 01 Nov 2017
35
References
Tumor Mutational Burden and Response Rate to PD-1 Inhibition
TL;DR: In a survey of the spectrum of mutational burdens in 27 types of cancers, there was a correlation between an increased mutational burden and the response to checkpoint inhibition of PD-1 and PD-L1.
International Germ Cell Consensus Classification: a prognostic factor-based staging system for metastatic germ cell cancers. International Germ Cell Cancer Collaborative Group.
Peter M Wilkinson,G Read +1 more
- 01 Feb 1997
TL;DR: An easily applicable, clinically based, prognostic classification for GCT has been agreed on between all the major clinical trial groups who are presently active worldwide and should be used in clinical practice and in the design and reporting of clinical trials to aid international collaboration and understanding.
1.8K
Treatment of Disseminated Germ-Cell Tumors with Cisplatin, Bleomycin, and either Vinblastine or Etoposide
Stephen D. Williams,Stephen D. Williams,R. Birch,R. Birch,Lawrence H. Einhorn,Irwin L,Irwin L,F A Greco,F A Greco,Patrick J. Loehrer +9 more
TL;DR: It is concluded that etoposide with cisplatin and bleomycin is superior to vinblastine with cisPlatin and Bleomycin in the treatment of disseminated germ-cell tumors because of diminished neuromuscular toxicity and, among patients with advanced disease, better efficacy.
1.1K
Guidelines on Testicular Cancer: 2015 Update.
Peter Albers,Walter Albrecht,Ferran Algaba,Carsten Bokemeyer,Gabriella Cohn-Cedermark,Karim Fizazi,Alan Horwich,M.P. Laguna,Nicola Nicolai,Jan Oldenburg +9 more
TL;DR: This publication focuses on the most important changes in treatment recommendations for clinical stage I disease and the updated recommendations for follow-up, which will lead to an overall reduction in treatment burden for patients with germ cell tumours.
641
Testicular germ-cell cancer
TL;DR: Advances in the understanding and management of TGCT during the past decade are summarized and include the reduction of chemotherapy for patients who have metastastic non-seminomas and a good prognosis, and alternatives to adjuvant radiotherapy in stage I seminomas.
620