Current Knowledge on Endocrine Disrupting Chemicals (EDCs) from Animal Biology to Humans, from Pregnancy to Adulthood: Highlights from a National Italian Meeting

Abstract: Additional file 1: Table S1. Detailed search strategies of the association between EDCs exposure and risk of EMs. Table S2. Quality assessment of studies included in the meta-analysis. Table S3. Subgroup analyses for association between maternal exposures to the EDC and serum TG in children. Fig S1. Funnel plot for serum triglyceride level. Fig S2. Funnel plot for serum total cholesterol in children. Table S4. Subgroup analysis of association between maternal exposures to the EDCs with serum HDL-C in children. Fig S3. Funnel plot for HDL- C in children. Fig S4. Funnel plot for SBP (A) and DBP (B) in children. Table S5. Subgroup analysis of association between maternal exposures to the EDCs and blood pressure in children. Table S6. Subgroup analysis of association between maternal exposures to the EDC with BMI and waist circumference z-score in children. Fig S5. Funnel plot for BMI and WC z-score in children.

TL;DR: The presence of endocrine-disrupting chemicals (EDCs) in commercial baby formula in Malawi poses a risk to infants. The levels of contamination ranged from not detected to 0.3 mg/kg, with common EDCs being Aldrin, dieldrin, and lindane. The risk assessment showed a Hazard Index of 1.2, suggesting that higher levels of exposure are more likely to have lasting effects during human development.

TL;DR: This narrative review synthesizes current evidence on micro- and nanoplastics exposure in children, highlighting organ-specific effects, routes of absorption, and emerging biomarkers, with a focus on pediatric lungs, thyroid, and intestinal microbiota, and potential long-term health consequences.

TL;DR: The objective is to describe the clinical management of patients in the ARTEMIS center, a prevention platform for environmental health dedicated to reproduction in France, where patient care also allows their physicians to become familiarized with environmental health.

TL;DR: The hypothesis is developed that retinoblastoma is a cancer caused by two mutational events, in the dominantly inherited form, one mutation is inherited via the germinal cells and the second occurs in somatic cells.

TL;DR: The evidence that endocrine disruptors have effects on male and female reproduction, breast development and cancer, prostate cancer, neuroendocrinology, thyroid, metabolism and obesity, and cardiovascular endocrinology is presented.

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TL;DR: Mechanisms underlying the disruption of the development of vital systems, such as the endocrine, reproductive, and immune systems, are discussed with reference to wildlife, laboratory animals, and humans.