Journal Article10.1002/ANGE.201107724
Curcumin – vom Molekül zur biologischen Wirkung
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TL;DR: Curcuma (Gelbwurzel) wird traditionell als Wurzmittel fur Lebensmittel eingesetzt. as discussed by the authors Theoretically, Curcuma is a wichtiger Bestandteil des Currypulvers and verleiht dem Pulver seine charakteristische Farbe.
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Abstract: Curcuma (Gelbwurzel) wird traditionell als Wurzmittel fur Lebensmittel eingesetzt. Curcumin ist ein wichtiger Bestandteil des Currypulvers und verleiht dem Pulver seine charakteristische Farbe. Aufgrund seiner intensiven gelben Farbe wird Curcuma bzw. Curcumin (Zusatzstoff E100) auch zum Farben von Lebensmitteln (z. B. Senf) verwendet. Curcuma enthalt die Curcuminoide Curcumin, Demethoxycurcumin und Bisdemethoxycurcumin. In jungster Zeit werden vermehrt gesundheitsfordernde Eigenschaften (Neuroprotektion, Chemo- bzw. Krebspravention) von Curcuminoiden diskutiert. Curcuminoide induzieren im Organismus endogene antioxidative Schutzsysteme und wirken entzundungshemmend. Curcuminoide beeinflussen die Genexpression sowie epigenetische Regulationsmechanismen. Synthetische Curcumin-Analoga zeigen zum Teil biologische Wirkungen. Dieser Aufsatz beschreibt die Entwicklung von Curcuma vom “traditionellen” Wurz- und Farbemittel zum “modernen” biologischen Regulator.
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Citations
Enhanced Drug Delivery by Dissolution of Amorphous Drug Encapsulated in a Water Unstable Metal–Organic Framework (MOF)
Kuthuru Suresh,Adam J. Matzger +1 more
TL;DR: The drug@MOF composites exhibit significantly enhanced dissolution and achieves high supersaturation in simulated gastric and/or phosphate buffer saline media and application to improve dissolution and solubility for the hydrophobic small drug molecules curcumin, sulindac, and triamterene is demonstrated.
279
Amino Acid Coordination Driven Self-Assembly for Enhancing both the Biological Stability and Tumor Accumulation of Curcumin.
TL;DR: The generation of supramolecular curcumin nanoagents through amino acid coordination driven self-assembly to simultaneously increase the biological stability and tumor accumulation ofCurcumin substantially enhanced the antitumor activity of Curcumin without discernible side effects.
207
Inhibition of Amyloid Fibril Growth and Dissolution of Amyloid Fibrils by Curcumin–Gold Nanoparticles
Sharbari Palmal,Amit Ranjan Maity,Brijesh Kumar Singh,Sreetama Basu,Nihar Ranjan Jana,Nikhil R. Jana +5 more
TL;DR: Curcumin-functionalized gold nanoparticles (Au-curcumin) of hydrodynamic diameter 10-25 nm are reported, which serve to inhibit amyloids fibrillation and disintegrate/dissolve amyloid fibrils, implying that nanoparticle-based artificial molecular chaperones may offer a promising therapeutic approach to combat neurodegenerative disease.
157
Novel Curcumin loaded nanoparticles engineered for Blood-Brain Barrier crossing and able to disrupt Abeta aggregates
Ruozi Barbara,Daniela Belletti,Francesca Pederzoli,Martina Masoni,Johannes Keller,Antonio Ballestrazzi,Maria Angela Vandelli,Giovanni Tosi,Andreas M. Grabrucker +8 more
TL;DR: C encapsulated Curcumin as active ingredient in PLGA (polylactide-co-glycolic-acid) nanoparticles (NPs), modified with g7 ligand for BBB crossing, showing no apparent toxicity of the formulated NPs, but a significant decrease of Aβ aggregates in response to CurCumin loaded NPs.
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The cis-Diammineplatinum(II) Complex of Curcumin: A Dual Action DNA Crosslinking and Photochemotherapeutic Agent
TL;DR: The fluorescence microscopic images showed cytosolic localization of curcumin, thus implying possibility of dual action as a chemo- and phototherapeutic agent.
117
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