Journal Article10.1002/BIOF.1057
Curcumin and liver disease
Laura Vera-Ramirez,Patricia Perez-Lopez,Alfonso Varela-López,MCarmen Ramirez-Tortosa,Maurizio Battino,José L. Quiles +5 more
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TL;DR: The effects of curcumin on NF‐κβ are crucial to the understanding of the potent hepatoprotective role of this herb‐derived micronutrient.
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Abstract: Liver diseases pose a major medical problem worldwide and a wide variety of herbs have been studied for the management of liver-related diseases. In this respect, curcumin has long been used in traditional medicine, and in recent years it has been the object of increasing research interest. In combating liver diseases, it seems clear that curcumin exerts a hypolipidic effect, which prevents the fatty acid accumulation in the hepatocytes that may result from metabolic imbalances, and which may cause nonalcoholic steatohepatitis. Another crucial protective activity of curcumin, not only in the context of chronic liver diseases but also regarding carcinogenesis and other age-related processes, is its potent antioxidant activity, which affects multiple processes and signaling pathways. The effects of curcumin on NF-κβ are crucial to our understanding of the potent hepatoprotective role of this herb-derived micronutrient. Because curcumin is a micronutrient that is closely related to cellular redox balance, its properties and activity give rise to a series of molecular reactions that in every case and biological situation affect the mitochondria.
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Citations
Curcumin: A Review of Its Effects on Human Health.
Susan Hewlings,Douglas S. Kalman +1 more
TL;DR: The purpose of this review is to provide a brief overview of the plethora of research regarding the health benefits ofCurcumin combined with enhancing agents provides multiple health benefits.
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Curcumin and Health
TL;DR: The origin, bioavailability and new research on curcumin and synthetized derivatives are reviewed, delving into aspects such as cancer, cardiovascular effects, metabolic syndrome, antioxidant capacity, anti-inflammatory properties, and neurological, liver and respiratory disorders.
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Curcumin in Liver Diseases: A Systematic Review of the Cellular Mechanisms of Oxidative Stress and Clinical Perspective
Mohammad Hosein Farzaei,Mahdi Zobeiri,Fatemeh Parvizi,Fardous F. El-Senduny,Ilias Marmouzi,Ericsson Coy-Barrera,Rozita Naseri,Seyed Mohammad Nabavi,Roja Rahimi,Mohammad Abdollahi +9 more
TL;DR: Electronic databases were extensively searched and results showed that curcumin exerts remarkable protective and therapeutic effects of oxidative associated liver diseases through various cellular and molecular mechanisms.
382
Protective effect of curcumin against heavy metals-induced liver damage.
TL;DR: Curcumin reduces the hepatotoxicity induced by arsenic, cadmium, chromium, copper, lead and mercury, prevents histological injury, lipid peroxidation and glutathione (GSH) depletion, maintains the liver antioxidant enzyme status and protects against mitochondrial dysfunction.
374
Curcumin as a potential candidate for treating hyperlipidemia: A review of cellular and metabolic mechanisms.
TL;DR: Taking together, curcumin could be used as a safe and well‐tolerated adjunct to statins to control hyperlipidaemia more effectively than statins alone.
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