Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends
Hardeep Singh Tuli,Prangya Rath,Abhishek Chauhan,Anuj Ranjan,Seema Ramniwas,Katrin Sak,Diwakar Aggarwal,Rajesh Kumar,Kuldeep Dhama,Kenneth Chun-Yong Yap,Sharah Mae Capinpin,Alan Prem Kumar +11 more
TL;DR: In this article , a review of cucumber-derived dietary lipids, highly oxidized tetracyclic triterpenoids, with potential medical uses is presented, focusing on the efforts undertaken to find possible molecular targets for cucurbitacins in suppressing diverse malignant processes.
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Abstract: Cucurbitacins constitute a group of cucumber-derived dietary lipids, highly oxidized tetracyclic triterpenoids, with potential medical uses. These compounds are known to interact with a variety of recognized cellular targets to impede the growth of cancer cells. Accumulating evidence has suggested that inhibition of tumor cell growth via induction of apoptosis, cell-cycle arrest, anti-metastasis and anti-angiogenesis are major promising chemo-preventive actions of cucurbitacins. Cucurbitacins may be a potential choice for investigations of synergism with other drugs to reverse cancer cells’ treatment resistance. The detailed molecular mechanisms underlying these effects include interactions between cucurbitacins and numerous cellular targets (Bcl-2/Bax, caspases, STAT3, cyclins, NF-κB, COX-2, MMP-9, VEGF/R, etc.) as well as control of a variety of intracellular signal transduction pathways. The current study is focused on the efforts undertaken to find possible molecular targets for cucurbitacins in suppressing diverse malignant processes. The review is distinctive since it presents all potential molecular targets of cucurbitacins in cancer on one common podium.
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Citations
Phytochemicals for the prevention and treatment of pancreatic cancer: Current progress and future prospects.
Nicolette Casarcia,Patrick Rogers,Emma Guld,Samvit Iyer,Yutong Li,J. T. Burcher,Lindsay K. DeLiberto,Anupam Bishayee +7 more
TL;DR: Aggregate results pooled from qualified studies indicate phytochemicals can inhibit pancreatic cancer cell growth or decrease tumor size and volume in animal models, and further in-depth studies are required to characterize the anticancer activities of phytochemical activities.
4
Structurally diverse cucurbitane-type triterpenoids from the tubers of Hemsleya chinensis with cytotoxic activity.
Xiao-San Li,Qi-Lin Wang,Zhi-Peng Xu,Ming-Shang Liu,Xiao-yan Liang,Jia-Chon Zheng,Hong-Yao Deng,Li Liu,Yongmei Huang,Mao-xun Yang,Xueqin Yang +10 more
TL;DR: Ten previously undescribed cucurbitane-type triterpenoids were isolated from Hemsleya chinensis tubers, exhibiting cytotoxic activity against various cancer cells, with compounds 17, 25, and 26 showing significant effects, particularly compound 25 inducing apoptosis and cell cycle arrest.
2
Therapeutic potential of dietary bioactive compounds against anti-apoptotic Bcl-2 proteins in breast cancer
Thripthi Nagesh Shenoy,Abdul Ajees Abdul Salam +1 more
TL;DR: This review explores the therapeutic potential of dietary bioactive compounds in modulating anti-apoptotic Bcl-2 proteins in breast cancer, highlighting their role in apoptosis regulation and treatment outcomes, with a focus on natural compounds from plants, fruits, and spices.
1
Synthetic Modifications of Therapeutically Relevant Pre-assembled Cucurbitacins: Synthetic Strategies and Structure-Activity Relationships
Rajat Sharma,Sobhana Thakur,Natish,Manvendra Kumar,Krishna Vamsi,Sanjay Jachak,Inder P. Singh,Raj Kumar +7 more
TL;DR: This study reviews synthetic modifications of therapeutically relevant pre-assembled cucurbitacins, discussing strategies, structure-activity relationships, and biological activities of chemically modified cucurbitacins, highlighting their potency, efficacy, and potential for improved drug delivery.
1
Exploring the Cucurbitacin E (CuE) as an Anti-Lung Cancer Lead Compound through Molecular Docking, ADMET, Pass Prediction and Drug Likeness Analysis
TL;DR: Cucurbitacin E (CuE) exhibits potent anti-lung cancer activity through molecular docking, ADMET, and PASS prediction, demonstrating strong ligand-protein interactions and favorable pharmacokinetic profiles, positioning CuE as a promising lead compound for lung cancer treatment.
1
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