Cu2+ inhibition of glycine-activated currents in rat sacral dorsal commissural neurons

TL;DR: Data indicate that presenilins are important for cellular copper and zinc turnover, influencing SOD1 activity, and having the potential to indirectly impact β-amyloid aggregation through metal ion clearance.

TL;DR: Using site-directed mutagenesis, it is shown that Asp128 plays a critical role in the copper activation of TREK-1 and TASK-3, and a novel explanation for how copper and zinc might affect neuronal excitability under both normal physiological conditions, as well as during diseases in which copper or zinc homeostasis has been disrupted.

TL;DR: A preponderance of transcriptional up-regulation of cardiac-specific genes suggests a mechanism of action whereby unilateral dephosphorylation of coded proteins resulted in a feedback loop of regulation (e.g., transcriptional activation of coding genes).

TL;DR: The coordination environment of Cu¬(+) in the human α1-glycine receptor (GlyR) is identified and it is shown that Cu²(+) has one binding site per α1 subunit, and that five Cuµ(+) can be coordinated per GlyR, and the coordination site does not include several residues of the agonist/antagonist binding site that were previously suggested to have roles in Cu´(+) coordination by functional measurements.

TL;DR: The results suggest that endogenous zinc and copper may act as allosteric neuromodulators of amino acid receptors on olfactory bulb neurons and may provide a mechanism for differential modulation of inhibitory transmission because of their distinct effects on glycine versus GABA receptors.

TL;DR: Analyses of the subcellular organelles prepared from different areas of the brain indicated that the concentrations of Cu and Zn were relatively larger in the hypothalamus and lower in cerebellum in comparison with other areas.

TL;DR: Cu2+ is a potent inhibitor of NMDA receptor‐mediated responses and interacts preferentially with agonist‐bound receptors, as well as analysis of the Cu2+ concentration‐response curve for inhibition ofNMDA‐induced currents suggests that free Cu2+.

TL;DR: The results suggest that Cu2+ and Zn2+ differentially modulate the function of P2X2 and P2 X4 receptors, perhaps because of differences in a shared site of action on both subunits or the absence of a site for Cu2- action on the P2x4 receptor.