Creatine and Creatinine Metabolism

TL;DR: Dietary cyclocreatine tempered autophagy, restored microglial clustering around plaques, and decreased plaque-adjacent neuronal dystrophy in TREM2-deficient mice with amyloid-β pathology, finding that TREM1 enables microglia responses during AD by sustaining cellular energetic and biosynthetic metabolism.

TL;DR: Experiments demonstrated that T cells from GCN2 knock-out mice did not show a decreased proliferation and were able to up-regulate cyclin D3 when cultured in the absence of L-Arg, contributing to the understanding of a central mechanism by which cancer and other diseases characterized by high arginase I production may cause T-cell dysfunction.

TL;DR: The crop plant model rice ( Oryza sativa) is used here as an example to highlight mechanisms and genes for adaptation of crop plants to drought stress.

TL;DR: It is demonstrated that creatine enhances respiration in beige-fat mitochondria when ADP is limiting and decreases whole-body energy expenditure after administration of a β3-agonist and reduces beige and brown adipose metabolic rate.

TL;DR: The ability of rabbit liver to activate MeIQx is dependent on CYP1A2 activity, the expression of which is developmentally regulated, and the inducibility of Me IQx activation increased with age, reaching a plateau between 17 and 35 days.

TL;DR: A new enzymatic assay involving the use of a mutant sarcosine oxidase, which was created as desired by site-directed mutagenesis and showed chloride-dependent activity, can easily and reliably be used for the accurate determination of chloride ion concentration in serum or other samples.

TL;DR: Four cases of Japanese patients with gyrate atrophy of the choroid and retina with hyperornithinemia and deficiency of ornithine ketoacid transaminase were examined, finding two types of disease in responsiveness to vitamin B6.