Journal Article10.1152/PHYSREV.2000.80.3.1107
Creatine and Creatinine Metabolism
Markus Wyss,Rima Kaddurah-Daouk +1 more
TL;DR: A comprehensive survey of the many intriguing facets of creatine (Cr) and creatinine metabolism is presented, encompassing the pathways and regulation of Cr biosynthesis and degradation, species and tissue distribution of the enzymes and metabolites involved, and of the inherent implications for physiology and human pathology.
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Abstract: The goal of this review is to present a comprehensive survey of the many intriguing facets of creatine (Cr) and creatinine metabolism, encompassing the pathways and regulation of Cr biosynthesis an...
read more
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Hypoxic control of metastasis.
Erinn B. Rankin,Amato J. Giaccia +1 more
TL;DR: Research focused on elucidating the mechanisms by which the hypoxic tumor microenvironment promotes metastatic progression is reviewed to identify potential biomarkers and therapeutic targets regulated by hypoxia that could be incorporated into strategies aimed at preventing and treating metastatic disease.
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TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.
Tyler K. Ulland,Wilbur M. Song,Stanley Ching-Cheng Huang,Jason D. Ulrich,Alexey Sergushichev,Wandy L. Beatty,Alexander A. Loboda,Yingyue Zhou,Nigel J. Cairns,Amal Kambal,Ekaterina Loginicheva,Susan Gilfillan,Marina Cella,Herbert W. Virgin,Emil R. Unanue,Yaming Wang,Maxim N. Artyomov,David M. Holtzman,Marco Colonna +18 more
TL;DR: Dietary cyclocreatine tempered autophagy, restored microglial clustering around plaques, and decreased plaque-adjacent neuronal dystrophy in TREM2-deficient mice with amyloid-β pathology, finding that TREM1 enables microglia responses during AD by sustaining cellular energetic and biosynthetic metabolism.
958
l-arginine availability regulates T-lymphocyte cell-cycle progression
TL;DR: Experiments demonstrated that T cells from GCN2 knock-out mice did not show a decreased proliferation and were able to up-regulate cyclin D3 when cultured in the absence of L-Arg, contributing to the understanding of a central mechanism by which cancer and other diseases characterized by high arginase I production may cause T-cell dysfunction.
889
Plant adaptation to drought stress.
TL;DR: The crop plant model rice ( Oryza sativa) is used here as an example to highlight mechanisms and genes for adaptation of crop plants to drought stress.
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A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat
Lawrence Kazak,Edward T. Chouchani,Mark P. Jedrychowski,Brian K. Erickson,Kosaku Shinoda,Paul Cohen,Ramalingam Vetrivelan,Gina Z. Lu,Dina Laznik-Bogoslavski,Sebastian C. Hasenfuss,Shingo Kajimura,Steve P. Gygi,Bruce M. Spiegelman +12 more
TL;DR: It is demonstrated that creatine enhances respiration in beige-fat mitochondria when ADP is limiting and decreases whole-body energy expenditure after administration of a β3-agonist and reduces beige and brown adipose metabolic rate.
689
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